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(2004). Rheumatic fever and rheumatic heart disease (Vol. 923).
Abstract: Rheumatic heart disease poses a major challenge to public health and is the most prevalent heart disease in children. The major determinants of rheumatic fever and rheumatic heart disease are poverty, malnutrition, overcrowding, poor housing, and a shortage of health-care resources. Although cost-effective strategies for the prevention and control of these diseases are available, they remain underutilized in most developing countries. A World Health Organization Expert Consultation reviewed the current scientific knowledge of rheumatic fever and rheumatic heart disease, as well as medical and public-health practices, and revised the Jones diagnostic criteria for rheumatic fever and rheumatic heart disease. This revision facilitates the diagnosis of: primary episodes of rheumatic fever, recurrent attacks of rheumatic fever in patients with or without rheumatic heart disease, rheumatic chorea, insidious onset rheumatic carditis and chronic rheumatic heart disease. The present report provides practical recommendations for an evidence-based approach to the prevention and management of rheumatic fever and rheumatic heart disease. It also provides practical guidance for implementing cost-effective programmes for controlling these diseases. The report will be of interest to clinicians, policy-makers and public-health professionals.
Keywords: Adolescent; Adult; Anti-Bacterial Agents/therapeutic use; Child; Child, Preschool; Chronic Disease; Echocardiography, Doppler; Endocarditis/diagnosis/therapy; Heart Valve Diseases/diagnosis/epidemiology/*microbiology/therapy; Humans; *Rheumatic Fever/diagnosis/epidemiology/physiopathology/therapy; Rheumatic Heart Disease/diagnosis/epidemiology/therapy; Streptococcus pyogenes/isolation & purification
Notes: PMID:15382606
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(2004). Rheumatic fever and rheumatic heart disease (Vol. 923).
Abstract: Rheumatic heart disease poses a major challenge to public health and is the most prevalent heart disease in children. The major determinants of rheumatic fever and rheumatic heart disease are poverty, malnutrition, overcrowding, poor housing, and a shortage of health-care resources. Although cost-effective strategies for the prevention and control of these diseases are available, they remain underutilized in most developing countries. A World Health Organization Expert Consultation reviewed the current scientific knowledge of rheumatic fever and rheumatic heart disease, as well as medical and public-health practices, and revised the Jones diagnostic criteria for rheumatic fever and rheumatic heart disease. This revision facilitates the diagnosis of: primary episodes of rheumatic fever, recurrent attacks of rheumatic fever in patients with or without rheumatic heart disease, rheumatic chorea, insidious onset rheumatic carditis and chronic rheumatic heart disease. The present report provides practical recommendations for an evidence-based approach to the prevention and management of rheumatic fever and rheumatic heart disease. It also provides practical guidance for implementing cost-effective programmes for controlling these diseases. The report will be of interest to clinicians, policy-makers and public-health professionals.
Keywords: Adolescent; Adult; Anti-Bacterial Agents/therapeutic use; Child; Child, Preschool; Chronic Disease; Echocardiography, Doppler; Endocarditis/diagnosis/therapy; Heart Valve Diseases/diagnosis/epidemiology/*microbiology/therapy; Humans; *Rheumatic Fever/diagnosis/epidemiology/physiopathology/therapy; Rheumatic Heart Disease/diagnosis/epidemiology/therapy; Streptococcus pyogenes/isolation & purification
Notes: PMID:15382606
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(2003). Mechanisms of abnormal cardiac repolarization during insulin-induced hypoglycemia.52(6), 1469–1474.
Abstract: Prolonged cardiac repolarization causes fatal cardiac arrhythmias. There is evidence that these contribute to sudden death associated with nocturnal hypoglycemia in young people with diabetes. We measured cardiac repolarization (QT interval [QTc] and QT dispersion [QTd]) during experimental hypoglycemia with and without beta-blockade and potassium infusion to establish possible mechanisms. Two groups of 10 nondiabetic men (study 1 and study 2) each underwent four hyperinsulinemic clamps: two euglycemic (5 mmol/l) and two hypoglycemic (5 mmol/l and 2.5 mmol/l for 60 min each). Study 1 was performed with and without potassium infusion to maintain normal concentrations and study 2 with and without beta-blockade (atenolol, 100 mg/day for 7 days). QTd was unchanged during euglycemia but increased during hypoglycemia (55 ms, P
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(2003). Mechanisms of abnormal cardiac repolarization during insulin-induced hypoglycemia.52(6), 1469–1474.
Abstract: Prolonged cardiac repolarization causes fatal cardiac arrhythmias. There is evidence that these contribute to sudden death associated with nocturnal hypoglycemia in young people with diabetes. We measured cardiac repolarization (QT interval [QTc] and QT dispersion [QTd]) during experimental hypoglycemia with and without beta-blockade and potassium infusion to establish possible mechanisms. Two groups of 10 nondiabetic men (study 1 and study 2) each underwent four hyperinsulinemic clamps: two euglycemic (5 mmol/l) and two hypoglycemic (5 mmol/l and 2.5 mmol/l for 60 min each). Study 1 was performed with and without potassium infusion to maintain normal concentrations and study 2 with and without beta-blockade (atenolol, 100 mg/day for 7 days). QTd was unchanged during euglycemia but increased during hypoglycemia (55 ms, P
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(2003). Quality Research Guidelines: As endorsed by the International Family Enterprise Research Academy (IFERA). Family Business Review, 16(2), 109–111.
Notes: 10.1111/j.1741-6248.2003.00109.x
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