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Author (up) Alami, D.; Dalpiaz, F. openurl 
  Title A Gamified Tutorial for Learning about Security Requirements Engineering Type Conference Article
  Year 2017 Publication Proceedings of the 25th International Requirements Engineering Conference, RE:Next! Track (RE17) Abbreviated Journal  
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  Notes Approved no  
  Call Number refbase @ admin @ AlamDalp2017 Serial 17575  
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Author (up) Austria, umweltbundesamt openurl 
  Title Production of Ammonia, Nitric Acid, Urea and N-Fertilizer Type Report
  Year 2017 Publication Abbreviated Journal  
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  Notes Approved no  
  Call Number refbase @ user @ umweltbundesamtaustriaProductionAmmoniaNitric2017 Serial 17714  
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Author (up) Bazzanella, A.; Ausfelder, F. openurl 
  Title Low Carbon Energy and Feedstock for the European Chemical Industry Technology Study Type Book Whole
  Year 2017 Publication Abbreviated Journal  
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  Keywords methanol synthesis  
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  Call Number refbase @ user @ bazzanellaLowCarbonEnergy2017 Serial 17596  
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Author (up) Berger, S.; Drews, R.; Helm, V.; Sun, S.; Pattyn, F. url  openurl
  Title Detecting high spatial variability of ice shelf basal mass balance, Roi Baudouin Ice Shelf, Antarctica Type Journal Article
  Year 2017 Publication The Cryosphere Abbreviated Journal  
  Volume 11 Issue 6 Pages 2675-2690  
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  ISSN 1994-0424 ISBN Medium  
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  Call Number refbase @ user @ berger_detecting_2017 Serial 17476  
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Author (up) Burnett, L.C.; LeDuc, C.A.; Sulsona, C.R.; Paull, D.; Rausch, R.; Eddiry, S.; Carli, J.F.M.; Morabito, M.V.; Skowronski, A.A.; Hubner, G.; Zimmer, M.; Wang, L.; Day, R.; Levy, B.; Fennoy, I.; Dubern, B.; Poitou, C.; Clement, K.; Butler, M.G.; Rosenbaum, M.; Salles, J.P.; Tauber, M.; Driscoll, D.J.; Egli, D.; Leibel, R.L. url  doi
openurl 
  Title Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome Type Journal Article
  Year 2017 Publication The Journal of Clinical Investigation Abbreviated Journal J Clin Invest  
  Volume 127 Issue 1 Pages 293-305  
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  Abstract Prader-Willi syndrome (PWS) is caused by a loss of paternally expressed genes in an imprinted region of chromosome 15q. Among the canonical PWS phenotypes are hyperphagic obesity, central hypogonadism, and low growth hormone (GH). Rare microdeletions in PWS patients define a 91-kb minimum critical deletion region encompassing 3 genes, including the noncoding RNA gene SNORD116. Here, we found that protein and transcript levels of nescient helix loop helix 2 (NHLH2) and the prohormone convertase PC1 (encoded by PCSK1) were reduced in PWS patient induced pluripotent stem cell-derived (iPSC-derived) neurons. Moreover, Nhlh2 and Pcsk1 expression were reduced in hypothalami of fasted Snord116 paternal knockout (Snord116p-/m+) mice. Hypothalamic Agrp and Npy remained elevated following refeeding in association with relative hyperphagia in Snord116p-/m+ mice. Nhlh2-deficient mice display growth deficiencies as adolescents and hypogonadism, hyperphagia, and obesity as adults. Nhlh2 has also been shown to promote Pcsk1 expression. Humans and mice deficient in PC1 display hyperphagic obesity, hypogonadism, decreased GH, and hypoinsulinemic diabetes due to impaired prohormone processing. Here, we found that Snord116p-/m+ mice displayed in vivo functional defects in prohormone processing of proinsulin, pro-GH-releasing hormone, and proghrelin in association with reductions in islet, hypothalamic, and stomach PC1 content. Our findings suggest that the major neuroendocrine features of PWS are due to PC1 deficiency.  
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  ISSN 0021-9738 ISBN Medium  
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  Notes PMID:27941249; PMCID:PMC5199710 Approved no  
  Call Number refbase @ user @ Serial 16636  
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