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Author (up) Hou, S.; Lu, P. url  doi
openurl 
  Title Direct reprogramming of somatic cells into neural stem cells or neurons for neurological disorders Type Journal Article
  Year 2016 Publication Neural Regeneration Research Abbreviated Journal Neural Regen Res  
  Volume 11 Issue 1 Pages 28-31  
  Keywords induced neural stem cells; induced neurons; neural cells; neurological diseases; pluripotent stem cells  
  Abstract Direct reprogramming of somatic cells into neurons or neural stem cells is one of the most important frontier fields in current neuroscience research. Without undergoing the pluripotency stage, induced neurons or induced neural stem cells are a safer and timelier manner resource in comparison to those derived from induced pluripotent stem cells. In this prospective, we review the recent advances in generation of induced neurons and induced neural stem cells in vitro and in vivo and their potential treatments of neurological disorders.  
  Address Veterans Administration Medical Center, San Diego, CA, USA; Department of Neurosciences, University of California at San Diego, La Jolla, CA, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1673-5374 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26981072; PMCID:PMC4774217 Approved no  
  Call Number refbase @ user @ Serial 16696  
Permanent link to this record
 

 
Author (up) Jhala, Y.V.; Isvaran, K. doi  isbn
openurl 
  Title Behavioural Ecology of a Grassland Antelope, the Blackbuck Antilope cervicapra: Linking Habitat, Ecology and Behaviour Type Book Chapter
  Year 2016 Publication The Ecology of Large Herbivores in South and Southeast Asia Abbreviated Journal  
  Volume Issue Pages 151-176  
  Keywords  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Springer Netherlands Place of Publication Dordrecht Editor Ahrestani, F.S.; Sankaran, M.  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 978-94-017-7570-0 Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number refbase @ user @ Jhala2016 Serial 16625  
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Author (up) Jodeiri Farshbaf, M.; Ghaedi, K.; Megraw, T.L.; Curtiss, J.; Shirani Faradonbeh, M.; Vaziri, P.; Nasr-Esfahani, M.H. url  doi
openurl 
  Title Does PGC1alpha/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders? Type Journal Article
  Year 2016 Publication Neuromolecular Medicine Abbreviated Journal Neuromolecular Med  
  Volume 18 Issue 1 Pages 1-15  
  Keywords Animals; Brain-Derived Neurotrophic Factor/*physiology; Cyclic AMP Response Element-Binding Protein/physiology; Energy Metabolism; Exercise/*physiology; Exercise Therapy; Feedback, Physiological; Fibronectins/*physiology; Humans; Mice; Mitochondria/physiology; Models, Neurological; Nerve Tissue Proteins/*physiology; Neurodegenerative Diseases/physiopathology/*prevention & control; Neurogenesis/physiology; Neurons/physiology/ultrastructure; Organelle Biogenesis; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/*physiology; Peroxisomes/physiology; Signal Transduction/*physiology; Bdnf; Fndc5; Irisin; Neurodegenerative diseases; Neuroprotection; PGC1alpha  
  Abstract Neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's diseases have high prevalence among the elderly. Many strategies have been established to alleviate the symptoms experienced by affected individuals. Recent studies have shown that exercise helps patients with neurological disorders to regain lost physical abilities. PGC1alpha/FNDC5/BDNF has emerged recently as a critical pathway for neuroprotection. PGC1alpha is a highly conserved co-activator of transcription factors that preserves and protects neurons against destruction. PGC1alpha regulates FNDC5 and its processed and secreted peptide Irisin, which has been proposed to play a critical role in energy expenditure and to promote neural differentiation of mouse embryonic stem cells. FNDC5 may also increase the expression of the neurotrophic factor BDNF, a neuroprotective agent, in the hippocampus. BDNF is secreted from hippocampus, amygdala, cerebral cortex and hypothalamus neurons and initiates intracellular signaling pathways through TrkB receptors. These pathways have positive feedback on CREB activities and lead to enhancement in PGC1alpha expression in neurons. Therefore, FNDC5 could behave as a key regulator in neuronal survival and development. This review presents recent findings on the PGC1alpha/FNDC5/BDNF pathway and its role in neuroprotection, and discusses the controversial promise of irisin as a mediator of the positive benefits of exercise.  
  Address Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Royan Street, Salman Street, Khorasgan, Isfahan, 8165131378, Iran. mh_nasr@royaninstitute.org  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1535-1084 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26611102 Approved no  
  Call Number refbase @ user @ Serial 16720  
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Author (up) Juan, A.H.; Wang, S.; Ko, K.D.; Zare, H.; Tsai, P.-F.; Feng, X.; Vivanco, K.O.; Ascoli, A.M.; Gutierrez-Cruz, G.; Krebs, J.; Sidoli, S.; Knight, A.L.; Pedersen, R.A.; Garcia, B.A.; Casellas, R.; Zou, J.; Sartorelli, V. url  doi
openurl 
  Title Roles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem Cells Type Journal Article
  Year 2016 Publication Cell Reports Abbreviated Journal Cell Rep  
  Volume 17 Issue 5 Pages 1369-1382  
  Keywords H3K27 methylation; embryonic stem cells; polycomb proteins  
  Abstract The polycomb repressive complex 2 (PRC2) methylates lysine 27 of histone H3 (H3K27) through its catalytic subunit Ezh2. PRC2-mediated di- and tri-methylation (H3K27me2/H3K27me3) have been interchangeably associated with gene repression. However, it remains unclear whether these two degrees of H3K27 methylation have different functions. In this study, we have generated isogenic mouse embryonic stem cells (ESCs) with a modified H3K27me2/H3K27me3 ratio. Our findings document dynamic developmental control in the genomic distribution of H3K27me2 and H3K27me3 at regulatory regions in ESCs. They also reveal that modifying the ratio of H3K27me2 and H3K27me3 is sufficient for the acquisition and repression of defined cell lineage transcriptional programs and phenotypes and influences induction of the ESC ground state.  
  Address Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: sartorev@mail.nih.gov  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2211-1247 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27783950; PMCID:PMC5123747 Approved no  
  Call Number refbase @ user @ Serial 16650  
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Author (up) Kelava, I.; Lancaster, M.A. url  doi
openurl 
  Title Dishing out mini-brains: Current progress and future prospects in brain organoid research Type Journal Article
  Year 2016 Publication Developmental Biology Abbreviated Journal Dev Biol  
  Volume 420 Issue 2 Pages 199-209  
  Keywords Cortex; Human brain development; In vitro; Neural differentiation; Neurological disorder; Organoid; Stem cells  
  Abstract The ability to model human brain development in vitro represents an important step in our study of developmental processes and neurological disorders. Protocols that utilize human embryonic and induced pluripotent stem cells can now generate organoids which faithfully recapitulate, on a cell-biological and gene expression level, the early period of human embryonic and fetal brain development. In combination with novel gene editing tools, such as CRISPR, these methods represent an unprecedented model system in the field of mammalian neural development. In this review, we focus on the similarities of current organoid methods to in vivo brain development, discuss their limitations and potential improvements, and explore the future venues of brain organoid research.  
  Address MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, CB2 0QH Cambridge, United Kingdom. Electronic address: mlancast@mrc-lmb.cam.ac.uk  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0012-1606 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27402594; PMCID:PMC5161139 Approved no  
  Call Number refbase @ user @ Serial 16667  
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