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Author (up) openurl 
  Title Type Miscellaneous
  Year 2016 Publication Abbreviated Journal  
  Volume Issue Pages  
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  Notes Approved no  
  Call Number refbase @ user @ ref32 Serial 17168  
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Author (up) openurl 
  Title Type Miscellaneous
  Year 2016 Publication Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
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  Area Expedition Conference  
  Notes Approved no  
  Call Number refbase @ user @ ref32 Serial 17284  
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Author (up) Achuta, V.S.; Grym, H.; Putkonen, N.; Louhivuori, V.; Karkkainen, V.; Koistinaho, J.; Roybon, L.; Castren, M.L. url  doi
openurl 
  Title Metabotropic glutamate receptor 5 responses dictate differentiation of neural progenitors to NMDA-responsive cells in fragile X syndrome Type Journal Article
  Year 2016 Publication Developmental Neurobiology Abbreviated Journal Dev Neurobiol  
  Volume Issue Pages  
  Keywords 2-methyl-6-(phenylethynyl)-pyridine; fragile X syndrome; glutamatergic neurons; induced pluripotent stem cells; metabotropic glutamate receptor 5  
  Abstract Disrupted metabotropic glutamate receptor 5 (mGluR5) signaling is implicated in many neuropsychiatric disorders, including autism spectrum disorder, found in fragile X syndrome (FXS). Here we report that intracellular calcium responses to the group I mGluR agonist (S)-3,5-dihydroxyphenylglycine (DHPG) are augmented, and calcium-dependent mGluR5-mediated mechanisms alter the differentiation of neural progenitors in neurospheres derived from human induced pluripotent FXS stem cells and the brains of mouse model of FXS. Treatment with the mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) prevents an abnormal clustering of DHPG-responsive cells that are responsive to activation of ionotropic receptors in mouse FXS neurospheres. MPEP also corrects morphological defects of differentiated cells and enhanced migration of neuron-like cells in mouse FXS neurospheres. Unlike in mouse neurospheres, MPEP increases the differentiation of DHPG-responsive radial glial cells as well as the subpopulation of cells responsive to both DHPG and activation of ionotropic receptors in human neurospheres. However, MPEP normalizes the FXS-specific increase in the differentiation of cells responsive only to N-methyl-d-aspartate (NMDA) present in human neurospheres. Exposure to MPEP prevents the accumulation of intermediate basal progenitors in embryonic FXS mouse brain suggesting that rescue effects of GluR5 antagonist are progenitor type-dependent and species-specific differences of basal progenitors may modify effects of MPEP on the cortical development. (c) 2016 Wiley Periodicals, Inc. Develop Neurobiol, 2016.  
  Address Autism Foundation, Kuortaneenkatu 7B, Helsinki, FI-00520, Finland  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 1932-8451 ISBN Medium  
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  Notes PMID:27411166 Approved no  
  Call Number refbase @ user @ Serial 16666  
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Author (up) Aguilera, C.A.; Aguilera, F.J.; Sappa, A.D.; Aguilera, C.; Toledo, R. openurl 
  Title Learning cross-spectral similarity measures with deep convolutional neural networks Type Conference Article
  Year 2016 Publication Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition Workshops Abbreviated Journal  
  Volume Issue Pages 1-9  
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  Notes Approved no  
  Call Number refbase @ user @ aguilera2016learning Serial 17108  
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Author (up) Alley, K.E.; Scambos, T.A.; Siegfried, M.R.; Fricker, H.A. url  openurl
  Title Impacts of warm water on Antarctic ice shelf stability through basal channel formation Type Journal Article
  Year 2016 Publication Nature Geoscience Abbreviated Journal  
  Volume advance online publication Issue Pages  
  Keywords Climate change, Cryospheric science  
  Abstract Antarcticas ice shelves provide resistance to the flow of grounded ice towards the ocean. If this resistance is decreased as a result of ice shelf thinning or disintegration, acceleration of grounded ice can occur, increasing rates of sea-level rise. Loss of ice shelf mass is accelerating, especially in West Antarctica, where warm seawater is reaching ocean cavities beneath ice shelves. Here we use satellite imagery, airborne ice-penetrating radar and satellite laser altimetry spanning the period from 2002 to 2014 to map extensive basal channels in the ice shelves surrounding Antarctica. The highest density of basal channels is found in West Antarctic ice shelves. Within the channels, warm water flows northwards, eroding the ice shelf base and driving channel evolution on annual to decadal timescales. Our observations show that basal channels are associated with the development of new zones of crevassing, suggesting that these channels may cause ice fracture. We conclude that basal channels can form and grow quickly as a result of warm ocean water intrusion, and that they can structurally weaken ice shelves, potentially leading to rapid ice shelf loss in some areas.  
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  Series Volume Series Issue Edition  
  ISSN 1752-0894 ISBN Medium  
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  Notes Approved no  
  Call Number refbase @ user @ alley_impacts_2016 Serial 17444  
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