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Author Hatch, M.N.; Nistor, G.; Keirstead, H.S. url  doi
openurl 
  Title Derivation of high-purity oligodendroglial progenitors Type Journal Article
  Year 2009 Publication Methods in Molecular Biology (Clifton, N.J.) Abbreviated Journal Methods Mol Biol  
  Volume (down) 549 Issue Pages 59-75  
  Keywords Animals; *Cell Culture Techniques/instrumentation/methods; Cell Differentiation/*physiology; Cell Shape; Cells, Cultured; Humans; Mice; Multipotent Stem Cells/cytology/*physiology; Oligodendroglia/cytology/*physiology; Stem Cells/cytology/*physiology  
  Abstract Oligodendrocytes are a type of glial cells that play a critical role in supporting the central nervous system (CNS), in particular insulating axons within the CNS by wrapping them with a myelin sheath, thereby enabling saltatory conduction. They are lost, and myelin damaged – demyelination – in a wide variety of neurological disorders. Replacing depleted cell types within demyelinated areas, however, has been shown experimentally to achieve remyelination and so help restore function. One method to produce oligodendrocytes for cellular replacement therapies is through the use of progenitor or stem cells. The ability to differentiate progenitor or stem cells into high-purity fates not only permits the generation of specific cells for transplantation therapies, but also provides powerful tools for studying cellular mechanisms of development. This chapter outlines methods of generating high-purity OPCs from multipotent neonatal progenitor or human embryonic stem cells.  
  Address Department of Anatomy and Neurobiology, Reeve-Irvine Research Center, University of California at Irvine, Irvine, CA, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1064-3745 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:19378196 Approved no  
  Call Number refbase @ user @ Serial 17025  
Permanent link to this record
 

 
Author Hanany, S.; Ade, P.; Balbi, A.; Bock, J.; Borrill, J.; Boscaleri, A.; De Bernardis, P.; Ferreira, P.G.; Hristov, V.V.; Jaffe, A.H.; others, url  openurl
  Title MAXIMA-1: a measurement of the cosmic microwave background anisotropy on angular scales of 10-5 Type Journal Article
  Year 2000 Publication The Astrophysical Journal Letters Abbreviated Journal  
  Volume (down) 545 Issue 1 Pages 5  
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  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number refbase @ user @ hanany_maxima-1:_2000 Serial 14343  
Permanent link to this record
 

 
Author Smith, D.M.; Kapoor, Y.; Klinzing, G.R.; Procopio, A.T. openurl 
  Title Pharmaceutical 3D printing: Design and qualification of a single step print and fill capsule Type Journal Article
  Year 2018 Publication International journal of pharmaceutics Abbreviated Journal  
  Volume (down) 544 Issue 1 Pages 21-30  
  Keywords 3D printing ; Additive manufacturing ; Analysis ; Burst release ; Capsule ; Delayed release ; Fused deposition modeling ; Hot melt extrusion ; Pharmaceutical industry ; Three dimensional printing  
  Abstract [Display omitted] Fused deposition modeling (FDM) 3D printing (3DP) has a potential to change how we envision manufacturing in the pharmaceutical industry. A more common utilization for FDM 3DP is to build upon existing hot melt extrusion (HME) technology where the drug is dispersed in the polymer matrix. However, reliable manufacturing of drug-containing filaments remains a challenge along with the limitation of active ingredients which can sustain the processing risks involved in the HME process. To circumvent this obstacle, a single step FDM 3DP process was developed to manufacture thin-walled drug-free capsules which can be filled with dry or liquid drug product formulations. Drug release from these systems is governed by the combined dissolution of the FDM capsule shell and the dosage form encapsulated in these shells. To prepare the shells, the 3D printer files (extension .gcode) were modified by creating discrete zones, so-called zoning process, with individual print parameters. Capsules printed without the zoning process resulted in macroscopic print defects and holes. X-ray computed tomography, finite element analysis and mechanical testing were used to guide the zoning process and printing parameters in order to manufacture consistent and robust capsule shell geometries. Additionally, dose consistencies of drug containing liquid formulations were investigated in this work.  
  Address  
  Corporate Author Thesis  
  Publisher Elsevier B.V Place of Publication Netherlands Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0378-5173 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number 1 @ metmet3 @ SmithDerrickM2018P3pD Serial 17797  
Permanent link to this record
 

 
Author Smith, D.M.; Kapoor, Y.; Klinzing, G.R.; Procopio, A.T. openurl 
  Title Pharmaceutical 3D printing: Design and qualification of a single step print and fill capsule Type Journal Article
  Year 2018 Publication International journal of pharmaceutics Abbreviated Journal  
  Volume (down) 544 Issue 1 Pages 21-30  
  Keywords 3D printing ; Additive manufacturing ; Analysis ; Burst release ; Capsule ; Delayed release ; Fused deposition modeling ; Hot melt extrusion ; Pharmaceutical industry ; Three dimensional printing  
  Abstract [Display omitted] Fused deposition modeling (FDM) 3D printing (3DP) has a potential to change how we envision manufacturing in the pharmaceutical industry. A more common utilization for FDM 3DP is to build upon existing hot melt extrusion (HME) technology where the drug is dispersed in the polymer matrix. However, reliable manufacturing of drug-containing filaments remains a challenge along with the limitation of active ingredients which can sustain the processing risks involved in the HME process. To circumvent this obstacle, a single step FDM 3DP process was developed to manufacture thin-walled drug-free capsules which can be filled with dry or liquid drug product formulations. Drug release from these systems is governed by the combined dissolution of the FDM capsule shell and the dosage form encapsulated in these shells. To prepare the shells, the 3D printer files (extension .gcode) were modified by creating discrete zones, so-called zoning process, with individual print parameters. Capsules printed without the zoning process resulted in macroscopic print defects and holes. X-ray computed tomography, finite element analysis and mechanical testing were used to guide the zoning process and printing parameters in order to manufacture consistent and robust capsule shell geometries. Additionally, dose consistencies of drug containing liquid formulations were investigated in this work.  
  Address  
  Corporate Author Thesis  
  Publisher Elsevier B.V Place of Publication Netherlands Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0378-5173 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number 1 @ metmet3 @ SmithDerrickM2018P3pD Serial 17807  
Permanent link to this record
 

 
Author Smith, D.M.; Kapoor, Y.; Klinzing, G.R.; Procopio, A.T. openurl 
  Title Pharmaceutical 3D printing: Design and qualification of a single step print and fill capsule Type Journal Article
  Year 2018 Publication International journal of pharmaceutics Abbreviated Journal  
  Volume (down) 544 Issue 1 Pages 21-30  
  Keywords 3D printing ; Additive manufacturing ; Analysis ; Burst release ; Capsule ; Delayed release ; Fused deposition modeling ; Hot melt extrusion ; Pharmaceutical industry ; Three dimensional printing  
  Abstract [Display omitted] Fused deposition modeling (FDM) 3D printing (3DP) has a potential to change how we envision manufacturing in the pharmaceutical industry. A more common utilization for FDM 3DP is to build upon existing hot melt extrusion (HME) technology where the drug is dispersed in the polymer matrix. However, reliable manufacturing of drug-containing filaments remains a challenge along with the limitation of active ingredients which can sustain the processing risks involved in the HME process. To circumvent this obstacle, a single step FDM 3DP process was developed to manufacture thin-walled drug-free capsules which can be filled with dry or liquid drug product formulations. Drug release from these systems is governed by the combined dissolution of the FDM capsule shell and the dosage form encapsulated in these shells. To prepare the shells, the 3D printer files (extension .gcode) were modified by creating discrete zones, so-called zoning process, with individual print parameters. Capsules printed without the zoning process resulted in macroscopic print defects and holes. X-ray computed tomography, finite element analysis and mechanical testing were used to guide the zoning process and printing parameters in order to manufacture consistent and robust capsule shell geometries. Additionally, dose consistencies of drug containing liquid formulations were investigated in this work.  
  Address  
  Corporate Author Thesis  
  Publisher Elsevier B.V Place of Publication Netherlands Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0378-5173 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number 1 @ metmet3 @ SmithDerrickM2018P3pD Serial 17817  
Permanent link to this record
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