| Records |
| Author |
Agnello, D.; Bigini, P.; Villa, P.; Mennini, T.; Cerami, A.; Brines, M.L.; Ghezzi, P. |
| Title |
Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis |
Type |
Journal Article |
| Year |
2002 |
Publication |
Brain Research |
Abbreviated Journal |
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Volume  |
952 |
Issue |
1 |
Pages |
128-134 |
| Keywords |
Animals; Anti-Inflammatory Agents/*pharmacology; Arthritis, Experimental/drug therapy/immunology; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental/*drug therapy/immunology; Erythropoietin/*pharmacology; Female; Interleukin-6/metabolism; Multiple Sclerosis/drug therapy/immunology; Rats; Rats, Inbred Lew; Research Support, Non-U.S. Gov't; Spinal Cord/immunology/metabolism; Tumor Necrosis Factor-alpha/metabolism |
| Abstract |
In recent work we reported that systemically administered erythropoietin (EPO) crosses the blood-brain barrier and has protective effects in animal models of cerebral ischemia, brain trauma and in a rat model of experimental autoimmune encephalomyelitis (EAE). Here we characterize the effect of systemic EPO on the inflammatory component of actively induced, acute EAE in Lewis rats. Administration of EPO at doses of 500-5000 U/kg bw i.p., daily from day 3 after immunization with myelin basic protein (MBP), delayed the onset of EAE and decreased its clinical score at peak time (days 12-13). Immunohistochemical analysis of the spinal cord using anti-glial fibrillary acidic protein (GFAP) and anti-CD11b antibodies showed that EPO markedly diminished inflammation and glial activation/proliferation. EAE induced significant levels of TNF and IL-6 in the spinal cord, where IL-6 was maximum at the onset of the disease (day 10) and TNF at its peak (day 12). EPO delayed the increase of TNF levels, without altering their peak levels, and markedly reduced those of IL-6 suggesting that the decreased inflammation and clinical score may be in part upon attenuation of IL-6. On the other hand, EPO was without effect in a model of adjuvant-induced arthritis in Lewis rats, suggesting a specificity towards autoimmune demyelinating diseases. These data suggest that EPO might act as a protective cytokine in inflammatory pathologies of the CNS. |
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0006-8993 (Print) Journal Article |
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refbase @ admin @ Agnello2002 |
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818 |
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| Author |
Jacob, F. |
| Title |
Complexity and tinkering |
Type |
Journal Article |
| Year |
2001 |
Publication |
Ann N Y Acad Sci |
Abbreviated Journal |
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| Volume |
929 |
Issue |
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Pages |
71-73 |
| Keywords |
Animals; Consciousness; Evolution, Molecular; Humans; Nerve Tissue Proteins; Neurons |
| Abstract |
All recent results in the fields of development and evolution point to a role of regulatory circuits as a major cause of evolutionary changes. |
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no |
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refbase @ user @ Jacob2001 |
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12119 |
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| Author |
Jacob, F. |
| Title |
Complexity and tinkering |
Type |
Journal Article |
| Year |
2001 |
Publication |
Ann N Y Acad Sci |
Abbreviated Journal |
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| Volume |
929 |
Issue |
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Pages |
71-73 |
| Keywords |
Animals; Consciousness; Evolution, Molecular; Humans; Nerve Tissue Proteins; Neurons |
| Abstract |
All recent results in the fields of development and evolution point to a role of regulatory circuits as a major cause of evolutionary changes. |
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refbase @ user @ Jacob2001 |
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12170 |
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Rheumatic fever and rheumatic heart disease |
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Report |
| Year |
2004 |
Publication |
World Health Organization Technical Report Series |
Abbreviated Journal |
World Health Organ Tech Rep Ser |
| Volume |
923 |
Issue |
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Pages |
1-122, back cover |
| Keywords |
Adolescent; Adult; Anti-Bacterial Agents/therapeutic use; Child; Child, Preschool; Chronic Disease; Echocardiography, Doppler; Endocarditis/diagnosis/therapy; Heart Valve Diseases/diagnosis/epidemiology/*microbiology/therapy; Humans; *Rheumatic Fever/diagnosis/epidemiology/physiopathology/therapy; Rheumatic Heart Disease/diagnosis/epidemiology/therapy; Streptococcus pyogenes/isolation & purification |
| Abstract |
Rheumatic heart disease poses a major challenge to public health and is the most prevalent heart disease in children. The major determinants of rheumatic fever and rheumatic heart disease are poverty, malnutrition, overcrowding, poor housing, and a shortage of health-care resources. Although cost-effective strategies for the prevention and control of these diseases are available, they remain underutilized in most developing countries. A World Health Organization Expert Consultation reviewed the current scientific knowledge of rheumatic fever and rheumatic heart disease, as well as medical and public-health practices, and revised the Jones diagnostic criteria for rheumatic fever and rheumatic heart disease. This revision facilitates the diagnosis of: primary episodes of rheumatic fever, recurrent attacks of rheumatic fever in patients with or without rheumatic heart disease, rheumatic chorea, insidious onset rheumatic carditis and chronic rheumatic heart disease. The present report provides practical recommendations for an evidence-based approach to the prevention and management of rheumatic fever and rheumatic heart disease. It also provides practical guidance for implementing cost-effective programmes for controlling these diseases. The report will be of interest to clinicians, policy-makers and public-health professionals. |
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0512-3054 |
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| Notes |
PMID:15382606 |
Approved |
no |
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refbase @ user @ |
Serial |
10454 |
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Rheumatic fever and rheumatic heart disease |
Type |
Report |
| Year |
2004 |
Publication |
World Health Organization Technical Report Series |
Abbreviated Journal |
World Health Organ Tech Rep Ser |
| Volume |
923 |
Issue |
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Pages |
1-122, back cover |
| Keywords |
Adolescent; Adult; Anti-Bacterial Agents/therapeutic use; Child; Child, Preschool; Chronic Disease; Echocardiography, Doppler; Endocarditis/diagnosis/therapy; Heart Valve Diseases/diagnosis/epidemiology/*microbiology/therapy; Humans; *Rheumatic Fever/diagnosis/epidemiology/physiopathology/therapy; Rheumatic Heart Disease/diagnosis/epidemiology/therapy; Streptococcus pyogenes/isolation & purification |
| Abstract |
Rheumatic heart disease poses a major challenge to public health and is the most prevalent heart disease in children. The major determinants of rheumatic fever and rheumatic heart disease are poverty, malnutrition, overcrowding, poor housing, and a shortage of health-care resources. Although cost-effective strategies for the prevention and control of these diseases are available, they remain underutilized in most developing countries. A World Health Organization Expert Consultation reviewed the current scientific knowledge of rheumatic fever and rheumatic heart disease, as well as medical and public-health practices, and revised the Jones diagnostic criteria for rheumatic fever and rheumatic heart disease. This revision facilitates the diagnosis of: primary episodes of rheumatic fever, recurrent attacks of rheumatic fever in patients with or without rheumatic heart disease, rheumatic chorea, insidious onset rheumatic carditis and chronic rheumatic heart disease. The present report provides practical recommendations for an evidence-based approach to the prevention and management of rheumatic fever and rheumatic heart disease. It also provides practical guidance for implementing cost-effective programmes for controlling these diseases. The report will be of interest to clinicians, policy-makers and public-health professionals. |
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0512-3054 |
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| Notes |
PMID:15382606 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
11128 |
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