| Records |
| Author |
Kunkanjanawan, T.; Noisa, P.; Parnpai, R. |
| Title |
Modeling neurological disorders by human induced pluripotent stem cells |
Type |
Journal Article |
| Year |
2011 |
Publication |
Journal of Biomedicine & Biotechnology |
Abbreviated Journal |
J Biomed Biotechnol |
Volume  |
2011 |
Issue |
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Pages |
350131 |
| Keywords |
Brain/embryology/physiopathology; Cell Differentiation; Embryonic Stem Cells/*cytology; Humans; Induced Pluripotent Stem Cells/*cytology/*physiology; *Models, Neurological; Nervous System Diseases/*pathology/*physiopathology/therapy |
| Abstract |
Studies of human brain development are critical as research on neurological disorders have been progressively advanced. However, understanding the process of neurogenesis through analysis of the early embryo is complicated and limited by a number of factors, including the complexity of the embryos, availability, and ethical constrains. The emerging of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) has shed light of a new approach to study both early development and disease pathology. The cells behave as precursors of all embryonic lineages; thus, they allow tracing the history from the root to individual branches of the cell lineage tree. Systems for neural differentiation of hESCs and iPSCs have provided an experimental model that can be used to augment in vitro studies of in vivo brain development. Interestingly, iPSCs derived from patients, containing donor genetic background, have offered a breakthrough approach to study human genetics of neurodegenerative diseases. This paper summarizes the recent reports of the development of iPSCs from patients who suffer from neurological diseases and evaluates the feasibility of iPSCs as a disease model. The benefits and obstacles of iPSC technology are highlighted in order to raising the cautions of misinterpretation prior to further clinical translations. |
| Address |
Embryo Technology and Stem Cell Research Center, School of Biotechnology, Suranaree University of Technology, 111 University Avenue, Nakhon Ratchasima 30000, Thailand |
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English |
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| ISSN |
1110-7243 |
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| Notes |
PMID:22162635; PMCID:PMC3227533 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
16958 |
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| Author |
Abshirini, H.; Rashidi, I.; Saki, N. |
| Title |
Pathologic fractures: a neglected clinical feature of parathyroid adenoma |
Type |
Journal Article |
| Year |
2010 |
Publication |
Case Reports in Medicine |
Abbreviated Journal |
Case Report Med |
| Volume |
2010 |
Issue |
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Pages |
357029 |
| Keywords |
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| Abstract |
The pattern of clinical presentation of primary hyperparathyroidism (pHPT) has changed dramatically from a severe disease to an asymptomatic condition in Western countries. The story is completely different in Eastern countries. Bone and joint related sign and symptoms like bone pain and multiple fractures are common in these patients. Imaging and nuclear medicine studies will be helpful specially in patient who candidate for surgical removal of the abnormal parathyroid gland. Here, we present a 48-year-old man with multiple typical fractures in long bones and a single adenoma in his right inferior parathyroid gland. pHPT is a severe, symptomatic disease with serious complications and high morbidity in Iran. Advanced skeletal disease is the most common pattern of presentation. |
| Address |
Otolaryngology, Head and Neck Surgery, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, P.O. Box 61537-15794, Ahvaz, Iran |
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English |
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1687-9635 |
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| Notes |
PMID:21209742 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
10153 |
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| Author |
Abshirini, H.; Rashidi, I.; Saki, N. |
| Title |
Pathologic fractures: a neglected clinical feature of parathyroid adenoma |
Type |
Journal Article |
| Year |
2010 |
Publication |
Case Reports in Medicine |
Abbreviated Journal |
Case Report Med |
| Volume |
2010 |
Issue |
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Pages |
357029 |
| Keywords |
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| Abstract |
The pattern of clinical presentation of primary hyperparathyroidism (pHPT) has changed dramatically from a severe disease to an asymptomatic condition in Western countries. The story is completely different in Eastern countries. Bone and joint related sign and symptoms like bone pain and multiple fractures are common in these patients. Imaging and nuclear medicine studies will be helpful specially in patient who candidate for surgical removal of the abnormal parathyroid gland. Here, we present a 48-year-old man with multiple typical fractures in long bones and a single adenoma in his right inferior parathyroid gland. pHPT is a severe, symptomatic disease with serious complications and high morbidity in Iran. Advanced skeletal disease is the most common pattern of presentation. |
| Address |
Otolaryngology, Head and Neck Surgery, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, P.O. Box 61537-15794, Ahvaz, Iran |
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English |
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1687-9635 |
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| Notes |
PMID:21209742 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
10827 |
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| Author |
Ahrens, J.; Jünemann, P. |
| Title |
Transitional institutions, institutional complementarities and economic performance in China: A ‘Varieties of Capitalism’ approach |
Type |
Journal Article |
| Year |
2010 |
Publication |
Ordnungspolitische Diskurse |
Abbreviated Journal |
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| Volume |
2010-11 |
Issue |
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Pages |
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| Keywords |
institutions; China; institutional change |
| Abstract |
Zusammenfassung: The paper focuses on institutional change and institution building as integral parts of economic transition in China. China’s success, particularly compared with other advanced transition economies, implies a puzzling observation: China did not apply. |
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no |
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refbase @ user @ Ahrens2010 |
Serial |
13003 |
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| Author |
Ahrens, J.; Jünemann, P. |
| Title |
Adaptive efficiency and pragmatic flexibility: characteristics of institutional change in capitalism, Chinese-style |
Type |
Journal Article |
| Year |
2009 |
Publication |
PFH Forschungspapiere |
Abbreviated Journal |
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| Volume |
2009 (03) |
Issue |
03 |
Pages |
23 |
| Keywords |
institutions; China; institutional change |
| Abstract |
Since the breakdown ofthe communist world, capitalism has been considered as the unrivalled model of economy and society–a conviction deeply rooted (not only) in Western culture (Miller 2005). The late 1980s and early 1990s saw a widespread ascendancy of. |
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no |
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refbase @ user @ Ahrens2009 |
Serial |
13002 |
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