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  Title (up) Type Book Whole
  Year 2517 Publication Abbreviated Journal  
  Volume Issue 155 Pages  
  Keywords , , , , , , ,  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 97486713211 Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number refbase @ admin @ ref__2517 Serial 11982  
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Author Swarztrauber, P.N. openurl 
  Title (up) Type Book Chapter
  Year 1982 Publication Vectorizing the FFTs Abbreviated Journal  
  Volume Issue Pages  
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  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Academic Press, New York Place of Publication Editor  Rodrigue, G.  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number refbase @ user @ Swa82 Serial 11993  
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Author {Resnik, P.}title openurl 
  Title (up) Type Conference Article
  Year Publication Abbreviated Journal  
  Volume Issue Pages  
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  Abstract  
  Address  
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  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Key: {}pages Approved no  
  Call Number refbase @ admin @ Resnik Serial 12029  
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Author {Yu, G.; Li, F.; Qin, Y.; Bo, X.; Wu, Y.; Wang, S.}T.I.T.L.E. url  openurl
  Title (up) Type Journal Article
  Year 2010 Publication Bioinformatics Abbreviated Journal  
  Volume 26 Issue 7 Pages 976-978  
  Keywords  
  Abstract  
  Address  
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  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1367-4811 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number refbase @ admin @ GOSemSim Serial 12030  
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Author Smyth, L.A.; Matthews, T.P.; Collins, I. openurl 
  Title (up) Type Journal Article
  Year Publication Abbreviated Journal Bioorganic & medicinal chemistry  
  Volume Issue Pages  
  Keywords Binding Sites Computer Simulation Drug Design Humans Indoles/chemistry Protein Kinase Inhibitors/chemical synthesis/*chemistry/pharmacology Protein Kinases/*chemistry/metabolism Pyridones/chem  
  Abstract A lead-like kinase inhibitor screening library containing new 3-aminopyrazolopyridinones and closely related compounds was designed that contained hydrogen-bond donor-acceptor motifs and substitution vectors inspired by the natural product kinase inhibitor indirubin. The solubility of the 3-aminopyrazolopyridinone scaffold was more than 1000-fold greater than that of indirubin itself, and solubility was enhanced by reduction of the proportion of lipophilic aryl substituents or the introduction of basic groups. Several components of the library showed kinase inhibitory activity. A subset of diaryl-substituted analogues preferentially inhibited tyrosine kinases with low micromolar activity and good ligand efficiency, and showed cellular antiproliferative activity. The evaluation of the library shows that new, non-natural compounds with relevant biological activity and improved physicochemical properties can be generated from the natural product indirubin, providing compounds that may be useful for kinase inhibitor drug discovery.  
  Address Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Belmont, Surrey SM2 5NG, UK.  
  Corporate Author Thesis  
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  ISSN ISBN Medium  
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  Notes Approved no  
  Call Number refbase @ user @ Serial 12890  
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