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Author |
Zerrouk, A.; Auguet, M.; Dabire, H.; Brisac, A.M.; Safar, M.; Chabrier, P.E. |
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Title |
Differential effects of tyrosine kinase inhibitors on contraction and relaxation of the aortas of normotensive and hypertensive rats |
Type |
Miscellaneous |
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Year |
1999 |
Publication |
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Abbreviated Journal |
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Volume |
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Issue |
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Pages |
49-58 |
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Keywords |
Differential, tyrosine, kinase, inhibitors, contraction, relaxation, hypertensive, hypertensive rats, rats, Animal, Aorta/drug effects/physiology, Calcium/metabolism, Carbachol/pharmacology, Endothelin 1/pharmacology, Hypertension/physiopathology, Indol |
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Abstract |
The contribution of tyrosine kinase activity to vasoreactivity in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats was investigated on isolated aortic preparations by the use of two tyrosine kinase inhibitors: methyl-2,5-dihydroxycinnamate (30 microM) and genistein (30 microM). The pretreatment of endothelium denuded aorta with methyl-2,5-dihydroxycinnamate reduced the sensitivity of the rings to noradrenaline to a larger extent in SHR than in WKY. The relaxing effects evoked by methyl-2,5-dihydroxycinnamate and genistein on the sustained contraction induced by endothelin-1 were also more pronounced in SHR denuded rings. Furthermore, in presence of methyl-2,5-dihydroxycinnamate, the endothelium-independent contractile responses to equipotent doses of cyclopiazonic acid were more depressed in SHR than in WKY. In WKY and SHR endothelium-intact aortas contracted with either phenylephrine or endothelin-1, carbachol and cyclopiazonic acid evoked endothelium derived relaxing factor (EDRF)/nitric oxide (NO)-dependent relaxations which were reduced by pretreatment of the rings with methyl-2,5-dihydroxycinnamate or genistein. These inhibitory effects were larger in WKY rings and more important on the cyclopiazonic acid response. In addition, sodium orthovanadate (30 microM) potentiated the noradrenaline-mediated contractions of endothelium-denuded SHR rings and reduced the cyclopiazonic acid-induced relaxation of endothelium-intact WKY rings. The present study suggests a regulatory role for tyrosine kinase in the smooth muscle contraction and the endothelium-dependent relaxation in WKY and SHR aortas and demonstrates the existence of a different relationship in the effect of tyrosine kinase inhibitors on vasoreactivity between SHR and WKY. We propose that an increase in the tyrosine kinase activity in SHR could lead to an enhanced reactivity of Ca2+-linked contractile mechanisms. In addition, our results suggest a link between the loss of tyrosine kinase activity and the altered endothelium-dependent relaxation associated with hypertension. |
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Journal Article |
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Series Volume  |
374 |
Series Issue |
1 |
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0014-2999 |
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no |
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Call Number |
refbase @ user @ Zerrouk1999 |
Serial |
9045 |
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Author |
Zerrouk, A.; Auguet, M.; Dabire, H.; Brisac, A.M.; Safar, M.; Chabrier, P.E. |
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Title |
Differential effects of tyrosine kinase inhibitors on contraction and relaxation of the aortas of normotensive and hypertensive rats |
Type |
Miscellaneous |
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Year |
1999 |
Publication |
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Abbreviated Journal |
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Volume |
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Issue |
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Pages |
49-58 |
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Keywords |
Differential, tyrosine, kinase, inhibitors, contraction, relaxation, hypertensive, hypertensive rats, rats, Animal, Aorta/drug effects/physiology, Calcium/metabolism, Carbachol/pharmacology, Endothelin 1/pharmacology, Hypertension/physiopathology, Indol |
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Abstract |
The contribution of tyrosine kinase activity to vasoreactivity in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats was investigated on isolated aortic preparations by the use of two tyrosine kinase inhibitors: methyl-2,5-dihydroxycinnamate (30 microM) and genistein (30 microM). The pretreatment of endothelium denuded aorta with methyl-2,5-dihydroxycinnamate reduced the sensitivity of the rings to noradrenaline to a larger extent in SHR than in WKY. The relaxing effects evoked by methyl-2,5-dihydroxycinnamate and genistein on the sustained contraction induced by endothelin-1 were also more pronounced in SHR denuded rings. Furthermore, in presence of methyl-2,5-dihydroxycinnamate, the endothelium-independent contractile responses to equipotent doses of cyclopiazonic acid were more depressed in SHR than in WKY. In WKY and SHR endothelium-intact aortas contracted with either phenylephrine or endothelin-1, carbachol and cyclopiazonic acid evoked endothelium derived relaxing factor (EDRF)/nitric oxide (NO)-dependent relaxations which were reduced by pretreatment of the rings with methyl-2,5-dihydroxycinnamate or genistein. These inhibitory effects were larger in WKY rings and more important on the cyclopiazonic acid response. In addition, sodium orthovanadate (30 microM) potentiated the noradrenaline-mediated contractions of endothelium-denuded SHR rings and reduced the cyclopiazonic acid-induced relaxation of endothelium-intact WKY rings. The present study suggests a regulatory role for tyrosine kinase in the smooth muscle contraction and the endothelium-dependent relaxation in WKY and SHR aortas and demonstrates the existence of a different relationship in the effect of tyrosine kinase inhibitors on vasoreactivity between SHR and WKY. We propose that an increase in the tyrosine kinase activity in SHR could lead to an enhanced reactivity of Ca2+-linked contractile mechanisms. In addition, our results suggest a link between the loss of tyrosine kinase activity and the altered endothelium-dependent relaxation associated with hypertension. |
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Summary Language |
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Original Title |
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Series Editor |
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Series Title |
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Abbreviated Series Title |
Journal Article |
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Series Volume |
374 |
Series Issue |
1 |
Edition |
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ISSN |
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ISBN |
0014-2999 |
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no |
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Call Number |
refbase @ user @ Zerrouk1999 |
Serial |
9237 |
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| Permanent link to this record |
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Author |
Zerrouk, A.; Auguet, M.; Dabire, H.; Brisac, A.M.; Safar, M.; Chabrier, P.E. |
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Title |
Differential effects of tyrosine kinase inhibitors on contraction and relaxation of the aortas of normotensive and hypertensive rats |
Type |
Miscellaneous |
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Year |
1999 |
Publication |
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Abbreviated Journal |
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Volume |
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Issue |
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Pages |
49-58 |
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Keywords |
Differential, tyrosine, kinase, inhibitors, contraction, relaxation, hypertensive, hypertensive rats, rats, Animal, Aorta/drug effects/physiology, Calcium/metabolism, Carbachol/pharmacology, Endothelin 1/pharmacology, Hypertension/physiopathology, Indol |
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Abstract |
The contribution of tyrosine kinase activity to vasoreactivity in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats was investigated on isolated aortic preparations by the use of two tyrosine kinase inhibitors: methyl-2,5-dihydroxycinnamate (30 microM) and genistein (30 microM). The pretreatment of endothelium denuded aorta with methyl-2,5-dihydroxycinnamate reduced the sensitivity of the rings to noradrenaline to a larger extent in SHR than in WKY. The relaxing effects evoked by methyl-2,5-dihydroxycinnamate and genistein on the sustained contraction induced by endothelin-1 were also more pronounced in SHR denuded rings. Furthermore, in presence of methyl-2,5-dihydroxycinnamate, the endothelium-independent contractile responses to equipotent doses of cyclopiazonic acid were more depressed in SHR than in WKY. In WKY and SHR endothelium-intact aortas contracted with either phenylephrine or endothelin-1, carbachol and cyclopiazonic acid evoked endothelium derived relaxing factor (EDRF)/nitric oxide (NO)-dependent relaxations which were reduced by pretreatment of the rings with methyl-2,5-dihydroxycinnamate or genistein. These inhibitory effects were larger in WKY rings and more important on the cyclopiazonic acid response. In addition, sodium orthovanadate (30 microM) potentiated the noradrenaline-mediated contractions of endothelium-denuded SHR rings and reduced the cyclopiazonic acid-induced relaxation of endothelium-intact WKY rings. The present study suggests a regulatory role for tyrosine kinase in the smooth muscle contraction and the endothelium-dependent relaxation in WKY and SHR aortas and demonstrates the existence of a different relationship in the effect of tyrosine kinase inhibitors on vasoreactivity between SHR and WKY. We propose that an increase in the tyrosine kinase activity in SHR could lead to an enhanced reactivity of Ca2+-linked contractile mechanisms. In addition, our results suggest a link between the loss of tyrosine kinase activity and the altered endothelium-dependent relaxation associated with hypertension. |
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Series Editor |
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Abbreviated Series Title |
Journal Article |
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Series Volume |
374 |
Series Issue |
1 |
Edition |
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ISSN |
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ISBN |
0014-2999 |
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Area |
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Expedition |
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Notes |
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Approved |
no |
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Call Number |
refbase @ user @ Zerrouk1999 |
Serial |
9429 |
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Author |
Hilmer, M |
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Title |
A model study of Arctic sea ice variability |
Type |
Book Whole |
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Year |
2001 |
Publication |
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Abbreviated Journal |
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Volume |
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Issue |
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Pages |
157 pp |
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Thesis |
Doctoral thesis |
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Publisher |
Inst Meereskunde |
Place of Publication |
Kiel |
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Language |
English |
Summary Language |
English; German |
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Berichte aus dem Institut für Meereskunde an der Christian-Albrechts-Universität Kiel |
Abbreviated Series Title |
Ber Inst Meereskd Christian-Albrechts-Univ Kiel |
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Series Volume |
320 |
Series Issue |
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Edition |
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ISSN |
0341-8561 |
ISBN |
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pp |
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Area |
Arctic Ocean |
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Notes |
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Approved |
yes |
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Call Number |
refbase @ user @ 468 |
Serial |
2 |
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Author |
Sparre, P.; Venema, S.C. |
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Title |
Introduction to tropical fish stock assessment. Part 1 – Manual |
Type |
Book Whole |
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Year |
1998 |
Publication |
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Abbreviated Journal |
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Volume |
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Issue |
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Pages |
407 pp |
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Keywords |
Age; Animal migration; Biomass; Computer software; Fishery resources; Growth; Mortality; Sampling; Statistical methods; Stock assessment; Surveys; Yields |
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Abstract |
In Part 1, Manual, a selection of methods on fish stock assessment is described in detail, with examples of calculations. Special emphasis is placed on methods based on the analysis of length-frequencies. After a short introduction to statistics, it covers the estimation of growth parameters and mortality rates, virtual population methods, including age-based and length-based cohort analysis, gear selectivity, sampling, prediction models, including Beverton and Holt's yield per recruit model and Thompson and Bell's model, surplus production models, multispecies and multifleet problems, the assessment of migratory stocks, a discussion on stock/recruitment relationships and demersal trawl surveys, including the swept-area method. The manual is completed with a review of stock assessment, where an indication is given of methods to be applied at different levels of availability of input data, a review of relevant computer programs produced by or in cooperation with FAO, and a list of references, including material for further reading. |
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Address |
Sparre: Danish Institute for Fisheries Research, Charlottenlund, Denmark; Venema: FAO Fisheries Department |
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Publisher |
FAO |
Place of Publication |
Rome |
Editor |
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Language |
English |
Summary Language |
English |
Original Title |
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Series Editor |
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Series Title |
FAO Fisheries Technical Paper |
Abbreviated Series Title |
FAO Fish Tech Pap |
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Series Volume |
306/1 |
Series Issue |
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Edition |
2 |
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ISSN |
0429-9345 |
ISBN |
92-5-103996-8 |
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Area |
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Expedition |
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Conference |
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Notes |
2nd revision (for 1st revision, see #28561) |
Approved |
no |
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Call Number |
refbase @ admin @ Sparre+Venema1998TropicalFish |
Serial |
4061 |
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