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Author Zerrouk, A.; Auguet, M.; Dabire, H.; Brisac, A.M.; Safar, M.; Chabrier, P.E.
Title Differential effects of tyrosine kinase inhibitors on contraction and relaxation of the aortas of normotensive and hypertensive rats Type Miscellaneous
Year 1999 Publication Abbreviated Journal
Volume Issue Pages 49-58
Keywords Differential, tyrosine, kinase, inhibitors, contraction, relaxation, hypertensive, hypertensive rats, rats, Animal, Aorta/drug effects/physiology, Calcium/metabolism, Carbachol/pharmacology, Endothelin 1/pharmacology, Hypertension/physiopathology, Indol
Abstract The contribution of tyrosine kinase activity to vasoreactivity in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats was investigated on isolated aortic preparations by the use of two tyrosine kinase inhibitors: methyl-2,5-dihydroxycinnamate (30 microM) and genistein (30 microM). The pretreatment of endothelium denuded aorta with methyl-2,5-dihydroxycinnamate reduced the sensitivity of the rings to noradrenaline to a larger extent in SHR than in WKY. The relaxing effects evoked by methyl-2,5-dihydroxycinnamate and genistein on the sustained contraction induced by endothelin-1 were also more pronounced in SHR denuded rings. Furthermore, in presence of methyl-2,5-dihydroxycinnamate, the endothelium-independent contractile responses to equipotent doses of cyclopiazonic acid were more depressed in SHR than in WKY. In WKY and SHR endothelium-intact aortas contracted with either phenylephrine or endothelin-1, carbachol and cyclopiazonic acid evoked endothelium derived relaxing factor (EDRF)/nitric oxide (NO)-dependent relaxations which were reduced by pretreatment of the rings with methyl-2,5-dihydroxycinnamate or genistein. These inhibitory effects were larger in WKY rings and more important on the cyclopiazonic acid response. In addition, sodium orthovanadate (30 microM) potentiated the noradrenaline-mediated contractions of endothelium-denuded SHR rings and reduced the cyclopiazonic acid-induced relaxation of endothelium-intact WKY rings. The present study suggests a regulatory role for tyrosine kinase in the smooth muscle contraction and the endothelium-dependent relaxation in WKY and SHR aortas and demonstrates the existence of a different relationship in the effect of tyrosine kinase inhibitors on vasoreactivity between SHR and WKY. We propose that an increase in the tyrosine kinase activity in SHR could lead to an enhanced reactivity of Ca2+-linked contractile mechanisms. In addition, our results suggest a link between the loss of tyrosine kinase activity and the altered endothelium-dependent relaxation associated with hypertension.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title Journal Article
Series Volume (down) 374 Series Issue 1 Edition
ISSN ISBN 0014-2999 Medium
Area Expedition Conference
Notes Approved no
Call Number refbase @ user @ Zerrouk1999 Serial 9045
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Author Zerrouk, A.; Auguet, M.; Dabire, H.; Brisac, A.M.; Safar, M.; Chabrier, P.E.
Title Differential effects of tyrosine kinase inhibitors on contraction and relaxation of the aortas of normotensive and hypertensive rats Type Miscellaneous
Year 1999 Publication Abbreviated Journal
Volume Issue Pages 49-58
Keywords Differential, tyrosine, kinase, inhibitors, contraction, relaxation, hypertensive, hypertensive rats, rats, Animal, Aorta/drug effects/physiology, Calcium/metabolism, Carbachol/pharmacology, Endothelin 1/pharmacology, Hypertension/physiopathology, Indol
Abstract The contribution of tyrosine kinase activity to vasoreactivity in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats was investigated on isolated aortic preparations by the use of two tyrosine kinase inhibitors: methyl-2,5-dihydroxycinnamate (30 microM) and genistein (30 microM). The pretreatment of endothelium denuded aorta with methyl-2,5-dihydroxycinnamate reduced the sensitivity of the rings to noradrenaline to a larger extent in SHR than in WKY. The relaxing effects evoked by methyl-2,5-dihydroxycinnamate and genistein on the sustained contraction induced by endothelin-1 were also more pronounced in SHR denuded rings. Furthermore, in presence of methyl-2,5-dihydroxycinnamate, the endothelium-independent contractile responses to equipotent doses of cyclopiazonic acid were more depressed in SHR than in WKY. In WKY and SHR endothelium-intact aortas contracted with either phenylephrine or endothelin-1, carbachol and cyclopiazonic acid evoked endothelium derived relaxing factor (EDRF)/nitric oxide (NO)-dependent relaxations which were reduced by pretreatment of the rings with methyl-2,5-dihydroxycinnamate or genistein. These inhibitory effects were larger in WKY rings and more important on the cyclopiazonic acid response. In addition, sodium orthovanadate (30 microM) potentiated the noradrenaline-mediated contractions of endothelium-denuded SHR rings and reduced the cyclopiazonic acid-induced relaxation of endothelium-intact WKY rings. The present study suggests a regulatory role for tyrosine kinase in the smooth muscle contraction and the endothelium-dependent relaxation in WKY and SHR aortas and demonstrates the existence of a different relationship in the effect of tyrosine kinase inhibitors on vasoreactivity between SHR and WKY. We propose that an increase in the tyrosine kinase activity in SHR could lead to an enhanced reactivity of Ca2+-linked contractile mechanisms. In addition, our results suggest a link between the loss of tyrosine kinase activity and the altered endothelium-dependent relaxation associated with hypertension.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title Journal Article
Series Volume (down) 374 Series Issue 1 Edition
ISSN ISBN 0014-2999 Medium
Area Expedition Conference
Notes Approved no
Call Number refbase @ user @ Zerrouk1999 Serial 9237
Permanent link to this record
 

 
Author Zerrouk, A.; Auguet, M.; Dabire, H.; Brisac, A.M.; Safar, M.; Chabrier, P.E.
Title Differential effects of tyrosine kinase inhibitors on contraction and relaxation of the aortas of normotensive and hypertensive rats Type Miscellaneous
Year 1999 Publication Abbreviated Journal
Volume Issue Pages 49-58
Keywords Differential, tyrosine, kinase, inhibitors, contraction, relaxation, hypertensive, hypertensive rats, rats, Animal, Aorta/drug effects/physiology, Calcium/metabolism, Carbachol/pharmacology, Endothelin 1/pharmacology, Hypertension/physiopathology, Indol
Abstract The contribution of tyrosine kinase activity to vasoreactivity in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats was investigated on isolated aortic preparations by the use of two tyrosine kinase inhibitors: methyl-2,5-dihydroxycinnamate (30 microM) and genistein (30 microM). The pretreatment of endothelium denuded aorta with methyl-2,5-dihydroxycinnamate reduced the sensitivity of the rings to noradrenaline to a larger extent in SHR than in WKY. The relaxing effects evoked by methyl-2,5-dihydroxycinnamate and genistein on the sustained contraction induced by endothelin-1 were also more pronounced in SHR denuded rings. Furthermore, in presence of methyl-2,5-dihydroxycinnamate, the endothelium-independent contractile responses to equipotent doses of cyclopiazonic acid were more depressed in SHR than in WKY. In WKY and SHR endothelium-intact aortas contracted with either phenylephrine or endothelin-1, carbachol and cyclopiazonic acid evoked endothelium derived relaxing factor (EDRF)/nitric oxide (NO)-dependent relaxations which were reduced by pretreatment of the rings with methyl-2,5-dihydroxycinnamate or genistein. These inhibitory effects were larger in WKY rings and more important on the cyclopiazonic acid response. In addition, sodium orthovanadate (30 microM) potentiated the noradrenaline-mediated contractions of endothelium-denuded SHR rings and reduced the cyclopiazonic acid-induced relaxation of endothelium-intact WKY rings. The present study suggests a regulatory role for tyrosine kinase in the smooth muscle contraction and the endothelium-dependent relaxation in WKY and SHR aortas and demonstrates the existence of a different relationship in the effect of tyrosine kinase inhibitors on vasoreactivity between SHR and WKY. We propose that an increase in the tyrosine kinase activity in SHR could lead to an enhanced reactivity of Ca2+-linked contractile mechanisms. In addition, our results suggest a link between the loss of tyrosine kinase activity and the altered endothelium-dependent relaxation associated with hypertension.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title Journal Article
Series Volume (down) 374 Series Issue 1 Edition
ISSN ISBN 0014-2999 Medium
Area Expedition Conference
Notes Approved no
Call Number refbase @ user @ Zerrouk1999 Serial 9429
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Author Hilmer, M
Title A model study of Arctic sea ice variability Type Book Whole
Year 2001 Publication Abbreviated Journal
Volume Issue Pages 157 pp
Keywords
Abstract
Address
Corporate Author Thesis Doctoral thesis
Publisher Inst Meereskunde Place of Publication Kiel Editor
Language English Summary Language English; German Original Title
Series Editor Series Title Berichte aus dem Institut für Meereskunde an der Christian-Albrechts-Universität Kiel Abbreviated Series Title Ber Inst Meereskd Christian-Albrechts-Univ Kiel
Series Volume (down) 320 Series Issue Edition
ISSN 0341-8561 ISBN Medium pp
Area Arctic Ocean Expedition Conference
Notes Approved yes
Call Number refbase @ user @ 468 Serial 2
Permanent link to this record
 

 
Author Sparre, P.; Venema, S.C.
Title Introduction to tropical fish stock assessment. Part 1 – Manual Type Book Whole
Year 1998 Publication Abbreviated Journal
Volume Issue Pages 407 pp
Keywords Age; Animal migration; Biomass; Computer software; Fishery resources; Growth; Mortality; Sampling; Statistical methods; Stock assessment; Surveys; Yields
Abstract In Part 1, Manual, a selection of methods on fish stock assessment is described in detail, with examples of calculations. Special emphasis is placed on methods based on the analysis of length-frequencies. After a short introduction to statistics, it covers the estimation of growth parameters and mortality rates, virtual population methods, including age-based and length-based cohort analysis, gear selectivity, sampling, prediction models, including Beverton and Holt's yield per recruit model and Thompson and Bell's model, surplus production models, multispecies and multifleet problems, the assessment of migratory stocks, a discussion on stock/recruitment relationships and demersal trawl surveys, including the swept-area method. The manual is completed with a review of stock assessment, where an indication is given of methods to be applied at different levels of availability of input data, a review of relevant computer programs produced by or in cooperation with FAO, and a list of references, including material for further reading.
Address Sparre: Danish Institute for Fisheries Research, Charlottenlund, Denmark; Venema: FAO Fisheries Department
Corporate Author Thesis
Publisher FAO Place of Publication Rome Editor
Language English Summary Language English Original Title
Series Editor Series Title FAO Fisheries Technical Paper Abbreviated Series Title FAO Fish Tech Pap
Series Volume (down) 306/1 Series Issue Edition 2
ISSN 0429-9345 ISBN 92-5-103996-8 Medium
Area Expedition Conference
Notes 2nd revision (for 1st revision, see #28561) Approved no
Call Number refbase @ admin @ Sparre+Venema1998TropicalFish Serial 4061
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