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Author Chaouche-teyara, K.; Fournier, B.; Safar, M.; Dabire, H. isbn  openurl
  Title Vascular and cardiac effects of alpha-methyl-5-HT and DOI are mediated by different 5-HT receptors in the pithed rat Type Miscellaneous
  Year 1993 Publication Abbreviated Journal  
  Volume Issue Pages 67-75  
  Keywords alpha-methyl-5-HT, DOI, 5-HT, 5-HT Receptors, Receptors, Pithed Rat, Rat, Alpha-methyl-5-hydroxytryptamine  
  Abstract In pithed rats, alpha-methyl-5-hydroxytryptamine (alpha-methyl-5-HT) increased blood pressure and heart rate, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) almost exclusively increased blood pressure and 1-(3-chlorophenyl)piperazine (mCPP), heart rate. The maximal responses relative to 5-HT indicate that alpha-methyl-5-HT may be a full agonist at vascular and cardiac 5-HT receptors, DOI a partial agonist at both receptors and mCPP a full agonist at cardiac 5-HT receptors but a partial agonist at vascular 5-HT receptors. The alpha 1-adrenoceptor antagonist, 2-[2-[4(o-methoxyphenyl)-piperazine-1-yl]-ethyl]4,4-dimethyl -1,3(2H-4H) isoquinolinedione (AR-C 239), did not change the pressor and tachycardiac effects of alpha-methyl-5-HT and DOI, excluding the participation of alpha 1-adrenoceptors. 4-Isopropyl-7-methyl-9-(2-hydroxy-1-methylpropoxycarbonyl) 4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline (LY 53857), spiperone and ketanserin but not propranolol antagonised the pressor effect of alpha-methyl-5-HT, indicating a preferential participation of 5-HT2 receptors although an implication of 5-HT1C receptors could not be ruled out. Spiperone, spiperone plus propranolol, LY 53857, ketanserin and propranolol antagonised the pressor effects of DOI suggesting the stimulation of both 5-HT2 and 5-HT1C receptors. Propranolol and spiperone plus propranolol suppressed the weak increase in heart rate induced by DOI, indicating the stimulation of 5-HT1C receptors. However, propranolol and LY 53857 only antagonised the tachycardiac effects of a high dose of alpha-methyl-5-HT. We hypothesised that the pressor and tachycardiac effects of these agonists may be mediated by 5-HT2 and 5-HT1C receptors, respectively. However, the availability of specific 5-HT1C and/or 5-HT2 receptor antagonists is necessary to verify our hypothesis and before a clear-cut conclusion can be drawn.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title Genuine article  
  Series Volume (down) 250 Series Issue 1 Edition  
  ISSN ISBN 0014-2999 Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number refbase @ user @ Chaouche-teyara1993b Serial 9278  
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Author Bhushan, N. url  isbn
openurl 
  Title Are Chemical Kinds Natural Kinds? Type Book Chapter
  Year 2006 Publication Philosophy Of Chemistry Abbreviated Journal  
  Volume Issue Pages 327-336  
  Keywords Humanities, Social Sciences and Law  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Springer Netherlands Place of Publication Editor Baird, D.; Scerri, E.; McIntyre, L.; Cohen, R.S.; Renn, J.; Gavroglu, K.; Divarci, L.  
  Language Summary Language Original Title  
  Series Editor Series Title Boston Studies in the Philosophy of Science Abbreviated Series Title  
  Series Volume (down) 242 Series Issue Edition  
  ISSN ISBN 978-1-4020-3261-5 Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number refbase @ user @ bhushan_are_2006 Serial 13990  
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Author Hendry, R.F. url  isbn
openurl 
  Title Is There Downward Causation in Chemistry? Type Book Chapter
  Year 2006 Publication Philosophy Of Chemistry Abbreviated Journal  
  Volume Issue Pages 173-189  
  Keywords Humanities, Social Sciences and Law  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Springer Netherlands Place of Publication Editor Baird, D.; Scerri, E.; McIntyre, L.; Cohen, R.S.; Renn, J.; Gavroglu, K.; Divarci, L.  
  Language Summary Language Original Title  
  Series Editor Series Title Boston Studies in the Philosophy of Science Abbreviated Series Title  
  Series Volume (down) 242 Series Issue Edition  
  ISSN ISBN 978-1-4020-3261-5 Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number refbase @ user @ hendry_is_2006 Serial 14371  
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Author Hunger, J. url  isbn
openurl 
  Title How Classical Models of Explanation Fail to Cope with Chemistry Type Book Chapter
  Year 2006 Publication Philosophy Of Chemistry Abbreviated Journal  
  Volume Issue Pages 129-156  
  Keywords Humanities, PoC, Social Sciences and Law  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Springer Netherlands Place of Publication Editor Baird, D.; Scerri, E.; McIntyre, L.; Cohen, R.S.; Renn, J.; Gavroglu, K.; Divarci, L.  
  Language Summary Language Original Title  
  Series Editor Series Title Boston Studies in the Philosophy of Science Abbreviated Series Title  
  Series Volume (down) 242 Series Issue Edition  
  ISSN ISBN 978-1-4020-3261-5 Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number refbase @ user @ hunger_how_2006 Serial 14406  
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Author Vemulapalli, G. url  isbn
openurl 
  Title Physics in the Crucible of Chemistry Type Book Chapter
  Year 2006 Publication Philosophy Of Chemistry Abbreviated Journal  
  Volume Issue Pages 191-204  
  Keywords Humanities, Social Sciences and Law  
  Abstract Well-established concepts in one area of science often find natural applications in other areas of science. In this regard, physics plays a pivotal role. Investigations in physics focus, for the most part, on systems with small number of actual or reduced variables and lead to firmly established concepts and fundamental laws. It is thus natural for chemistry to look into physics for guidance as it explores the unknown territories. The main thesis of the article is that physical laws are about limitations. While they set the boundaries within which chemical mechanisms must fall, they cannot dictate the actual mechanisms. Thus, chemistry has to be viewed as both dependent and independent of physics. The relation between physics and other areas of scientific inquiry is likely to follow the pattern described here: within the possibilities allowed by physics, scientists have to look for explanations that depend on factors outside physics.  
  Address  
  Corporate Author Thesis  
  Publisher Springer Netherlands Place of Publication Editor Baird, D.; Scerri, E.; McIntyre, L.; Cohen, R.S.; Renn, J.; Gavroglu, K.; Divarci, L.  
  Language Summary Language Original Title  
  Series Editor Series Title Boston Studies in the Philosophy of Science Abbreviated Series Title  
  Series Volume (down) 242 Series Issue Edition  
  ISSN ISBN 978-1-4020-3261-5 Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number refbase @ user @ vemulapalli_physics_2006 Serial 15037  
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