| |
Records |
Links |
|
Author |
Saraiva, L.; Fresco, P.; Pinto, E.; Sousa, E.; Pinto, M.; Goncalves, J. |
|
| |
Title |
Synthesis and in vivo modulatory activity of protein kinase C of xanthone derivatives |
Type |
Journal Article |
| |
Year |
2002 |
Publication |
Bioorganic and Medicinal Chemistry |
Abbreviated Journal |
|
|
| |
Volume |
10 |
Issue |
10 |
Pages |
3219-3227 |
|
| |
Keywords |
|
|
| |
Abstract |
The modulatory activity of a series of 20 simple xanthones on isoforms @a, @bI, @d, @h and @z of protein kinase C (PKC) was evaluated using an in vivo yeast phenotypic assay. Hydroxy and/or methoxyxanthones were synthesised. The majority... |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher  |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
refbase @ user @ |
Serial |
425 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
N K Mak,; H L Lung,; R N Wong,; H W Leung,; H Y Tsang,; K N Leung, |
|
| |
Title |
Expression of protein kinase C isoforms in euxanthone-induced differentiation of neuroblastoma cells |
Type |
Journal Article |
| |
Year |
2001 |
Publication |
Planta Med |
Abbreviated Journal |
|
|
| |
Volume |
67 |
Issue |
5 |
Pages |
400-405 |
|
| |
Keywords |
Animals; Antineoplastic Agents, Phytogenic; Carbazoles; Cell Differentiation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Indoles; Isoenzymes; Mice; Neurites; Neuroblastoma; Protein Kinase C; Research Support, Non-U.S. Gov't; Rosales; Staurosporine; Xanthenes; Xanthones |
|
| |
Abstract |
Euxanthone, a potent neuritogenic compound isolated from the roots of the medicinal herb Polygala caudata, has recently been shown to induce the differentiation of murine neuroblastoma Neuro 2A (BU-1) cells. In this study, the role of protein kinase C... |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
refbase @ user @ |
Serial |
426 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Lucília Saraiva,; Paula Fresco,; Eugénia Pinto,; Anake Kijjoa,; Maria José Gonzalez,; Jorge Gonçalves, |
|
| |
Title |
Differential activation of protein kinase C isoforms by euxanthone, revealed by an in vivo yeast phenotypic assay |
Type |
Journal Article |
| |
Year |
2002 |
Publication |
Planta Med |
Abbreviated Journal |
|
|
| |
Volume |
68 |
Issue |
11 |
Pages |
1039-1041 |
|
| |
Keywords |
Clusiaceae; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Isoenzymes; Phenotype; Phytotherapy; Protein Kinase C; Xanthenes; Xanthones; Yeasts |
|
| |
Abstract |
The protein kinase C (PKC) modulatory effects of euxanthone, isolated from the wood of Cratoxylum maingayi, on isoforms alpha, betaI, delta, eta and zeta were characterised using an alternative in vivo yeast phenotypic assay. The present study shows... |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
refbase @ user @ |
Serial |
423 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Lucília Saraiva,; Paula Fresco,; Eugénia Pinto,; Emília Sousa,; Madalena Pinto,; Jorge Gonçalves, |
|
| |
Title |
Synthesis and in vivo modulatory activity of protein kinase C of xanthone derivatives |
Type |
Journal Article |
| |
Year |
2002 |
Publication |
Bioorg Med Chem |
Abbreviated Journal |
|
|
| |
Volume |
10 |
Issue |
10 |
Pages |
3219-3227 |
|
| |
Keywords |
Animals; Cell Division; Enzyme Activation; Humans; Isoenzymes; Mammals; Protein Kinase C; Research Support, Non-U.S. Gov't; Structure-Activity Relationship; Transformation, Genetic; Xanthenes; Xanthones; Yeasts |
|
| |
Abstract |
The modulatory activity of a series of 20 simple xanthones on isoforms alpha, betaI, delta, eta and zeta of protein kinase C (PKC) was evaluated using an in vivo yeast phenotypic assay. Hydroxy and/or methoxyxanthones were synthesised. The majority of... |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
refbase @ user @ |
Serial |
424 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Saraiva, L.; Fresco, P.; Pinto, E.; Sousa, E.; Pinto, M.; Goncalves, J. |
|
| |
Title |
Inhibition of protein kinase C by synthetic xanthone derivatives |
Type |
Journal Article |
| |
Year |
2003 |
Publication |
Bioorganic and Medicinal Chemistry |
Abbreviated Journal |
|
|
| |
Volume |
11 |
Issue |
7 |
Pages |
1215-1225 |
|
| |
Keywords |
|
|
| |
Abstract |
The modulatory activity of two xanthones (3,4-dihydroxyxanthone and 1-formyl-4-hydroxy-3-methoxyxanthone) on isoforms @a, @bI, @d, @h and @z of protein kinase C (PKC) was evaluated using an in vivo yeast phenotypic assay. Both xanthones... |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
refbase @ user @ |
Serial |
421 |
|
| Permanent link to this record |
