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Author Pedro, M.; Cerqueira, F.; Sousa, M.E.; Nascimento, M.S.J.; Pinto, M. url  openurl
  Title Xanthones as inhibitors of growth of human cancer cell lines and Their effects on the proliferation of human.. Type Journal Article
  Year 2002 Publication Bioorganic and Medicinal Chemistry Abbreviated Journal  
  Volume 10 Issue 12 Pages 3725-3730  
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  Abstract Twenty-seven oxygenated xanthones have been assessed for their capacity to inhibit in vitro the growth of three human cancer cell lines, MCF-7 (breast cancer), TK-10 (renal cancer) and UACC-62 (melanoma). The effect of these xanthones on...  
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  Notes (up) Approved no  
  Call Number refbase @ user @ Serial 422  
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Author Lucília Saraiva,; Paula Fresco,; Eugénia Pinto,; Emília Sousa,; Madalena Pinto,; Jorge Gonçalves, url  openurl
  Title Inhibition of protein kinase C by synthetic xanthone derivatives Type Journal Article
  Year 2003 Publication Bioorg Med Chem Abbreviated Journal  
  Volume 11 Issue 7 Pages 1215-1225  
  Keywords Arachidonic Acid; Enzyme Inhibitors; Immunoblotting; Immunochemistry; Indicators and Reagents; Isoenzymes; Phenanthridines; Phenotype; Phosphatidylserines; Piperidines; Plasmids; Protein Kinase C; Research Support, Non-U.S. Gov't; Saccharomyces cerevisiae; Tetradecanoylphorbol Acetate; Xanthines  
  Abstract The modulatory activity of two xanthones (3,4-dihydroxyxanthone and 1-formyl-4-hydroxy-3-methoxyxanthone) on isoforms alpha, betaI, delta, eta and zeta of protein kinase C (PKC) was evaluated using an in vivo yeast phenotypic assay. Both xanthones...  
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  Notes (up) Approved no  
  Call Number refbase @ user @ Serial 420  
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Author Lucília Saraiva,; Paula Fresco,; Eugénia Pinto,; Emília Sousa,; Madalena Pinto,; Jorge Gonçalves, url  openurl
  Title Inhibition of alpha, betaI, delta, eta, and zeta protein kinase C isoforms by xanthonolignoids Type Journal Article
  Year 2003 Publication J Enzyme Inhib Med Chem Abbreviated Journal  
  Volume 18 Issue 4 Pages 357-370  
  Keywords Animals; Arachidonic Acid; Computer Simulation; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Isoenzymes; Phenanthridines; Protein Kinase C; Rats; Research Support, Non-U.S. Gov't; Xanthones; Yeasts  
  Abstract The effect of the xanthonolignoids trans-(+/-)-kielcorin C, cis-(+/-)-kielcorin C, trans-(+/-)-kielcorin D, trans-(+/-)-isokielcorin D and trans-(+/-)-kielcorin E on isoforms alpha, betaI, delta, eta and zeta of protein kinase C (PKC) was studied using...  
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  Notes (up) Approved no  
  Call Number refbase @ user @ Serial 419  
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Author Ho Y Yeung,; Daniel K O Chan,; Nai K Mak,; Graham F Wagner,; Chris K C Wong, url  openurl
  Title Identification of signal transduction pathways that modulate dibutyryl cyclic adenosine monophosphate activation of.. Type Journal Article
  Year 2003 Publication Endocrinology Abbreviated Journal  
  Volume 144 Issue 10 Pages 4446-4452  
  Keywords Animals; Antineoplastic Agents; Bucladesine; Calcium; Cell Differentiation; Drug Interactions; Gene Expression Regulation; Glycoproteins; Hormones; Mice; Neuroblastoma; RNA, Messenger; Research Support, Non-U.S. Gov't; Signal Transduction; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured; Xanthenes; Xanthones  
  Abstract Stanniocalcin (STC) is a new mammalian polypeptide hormone and appears to be a regulator of neuronal function. We have already shown that the induction of STC mRNA and protein expression by cAMP is integral to neuroblastoma cell differentiation,...  
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  Notes (up) Approved no  
  Call Number refbase @ user @ Serial 418  
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Author Vamsidhara C Dhulipala,; Umesh M Hanumegowda,; Ganesh Balasubramanian,; Chada S Reddy, url  openurl
  Title Relevance of the palatal protein kinase A pathway to the pathogenesis of cleft palate by secalonic acid D in mice Type Journal Article
  Year 2004 Publication Toxicol Appl Pharmacol Abbreviated Journal  
  Volume 194 Issue 3 Pages 270-279  
  Keywords Animals; Blotting, Western; Catalysis; Cell Division; Cell Nucleus; Cleft Palate; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Protein, Cyclic AMP-Responsive; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Female; Gene Expression; Mice; Palate; Phosphorylation; Pregnancy; Proliferating Cell Nuclear Antigen; Protein Kinase C; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Response Elements; Signal Transduction; Teratogens; Transcription Factors; Xanthones  
  Abstract Secalonic acid-D (SAD) is a teratogenic mycotoxin inducing cleft palate (CP) in the offspring of the exposed mice by reducing palatal shelf size secondary to reduced proliferation of the palatal mesenchymal (PM) cells. Co-administration of...  
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  Notes (up) Approved no  
  Call Number refbase @ user @ Serial 417  
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