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Author Saraiva, L.; Fresco, P.; Pinto, E.; Sousa, E.; Pinto, M.; Goncalves, J. url  openurl
  Title Synthesis and in vivo modulatory activity of protein kinase C of xanthone derivatives Type Journal Article
  Year 2002 Publication Bioorganic and Medicinal Chemistry Abbreviated Journal  
  Volume 10 Issue 10 Pages 3219-3227  
  Keywords  
  Abstract The modulatory activity of a series of 20 simple xanthones on isoforms @a, @bI, @d, @h and @z of protein kinase C (PKC) was evaluated using an in vivo yeast phenotypic assay. Hydroxy and/or methoxyxanthones were synthesised. The majority...  
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  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
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  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes (up) Approved no  
  Call Number refbase @ user @ Serial 425  
Permanent link to this record
 

 
Author N K Mak,; H L Lung,; R N Wong,; H W Leung,; H Y Tsang,; K N Leung, url  openurl
  Title Expression of protein kinase C isoforms in euxanthone-induced differentiation of neuroblastoma cells Type Journal Article
  Year 2001 Publication Planta Med Abbreviated Journal  
  Volume 67 Issue 5 Pages 400-405  
  Keywords Animals; Antineoplastic Agents, Phytogenic; Carbazoles; Cell Differentiation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Indoles; Isoenzymes; Mice; Neurites; Neuroblastoma; Protein Kinase C; Research Support, Non-U.S. Gov't; Rosales; Staurosporine; Xanthenes; Xanthones  
  Abstract Euxanthone, a potent neuritogenic compound isolated from the roots of the medicinal herb Polygala caudata, has recently been shown to induce the differentiation of murine neuroblastoma Neuro 2A (BU-1) cells. In this study, the role of protein kinase C...  
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  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes (up) Approved no  
  Call Number refbase @ user @ Serial 426  
Permanent link to this record
 

 
Author Lucília Saraiva,; Paula Fresco,; Eugénia Pinto,; Anake Kijjoa,; Maria José Gonzalez,; Jorge Gonçalves, url  openurl
  Title Differential activation of protein kinase C isoforms by euxanthone, revealed by an in vivo yeast phenotypic assay Type Journal Article
  Year 2002 Publication Planta Med Abbreviated Journal  
  Volume 68 Issue 11 Pages 1039-1041  
  Keywords Clusiaceae; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Isoenzymes; Phenotype; Phytotherapy; Protein Kinase C; Xanthenes; Xanthones; Yeasts  
  Abstract The protein kinase C (PKC) modulatory effects of euxanthone, isolated from the wood of Cratoxylum maingayi, on isoforms alpha, betaI, delta, eta and zeta were characterised using an alternative in vivo yeast phenotypic assay. The present study shows...  
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  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes (up) Approved no  
  Call Number refbase @ user @ Serial 423  
Permanent link to this record
 

 
Author Lucília Saraiva,; Paula Fresco,; Eugénia Pinto,; Emília Sousa,; Madalena Pinto,; Jorge Gonçalves, url  openurl
  Title Synthesis and in vivo modulatory activity of protein kinase C of xanthone derivatives Type Journal Article
  Year 2002 Publication Bioorg Med Chem Abbreviated Journal  
  Volume 10 Issue 10 Pages 3219-3227  
  Keywords Animals; Cell Division; Enzyme Activation; Humans; Isoenzymes; Mammals; Protein Kinase C; Research Support, Non-U.S. Gov't; Structure-Activity Relationship; Transformation, Genetic; Xanthenes; Xanthones; Yeasts  
  Abstract The modulatory activity of a series of 20 simple xanthones on isoforms alpha, betaI, delta, eta and zeta of protein kinase C (PKC) was evaluated using an in vivo yeast phenotypic assay. Hydroxy and/or methoxyxanthones were synthesised. The majority of...  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes (up) Approved no  
  Call Number refbase @ user @ Serial 424  
Permanent link to this record
 

 
Author Saraiva, L.; Fresco, P.; Pinto, E.; Sousa, E.; Pinto, M.; Goncalves, J. url  openurl
  Title Inhibition of protein kinase C by synthetic xanthone derivatives Type Journal Article
  Year 2003 Publication Bioorganic and Medicinal Chemistry Abbreviated Journal  
  Volume 11 Issue 7 Pages 1215-1225  
  Keywords  
  Abstract The modulatory activity of two xanthones (3,4-dihydroxyxanthone and 1-formyl-4-hydroxy-3-methoxyxanthone) on isoforms @a, @bI, @d, @h and @z of protein kinase C (PKC) was evaluated using an in vivo yeast phenotypic assay. Both xanthones...  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes (up) Approved no  
  Call Number refbase @ user @ Serial 421  
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