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Author |
Ha, H.-Y.; Jang, S.-H.; Jung, J.-W. |
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Title |
The use of pluripotent stem cell for personalized cell therapies against neurological disorders |
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Journal Article |
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Year |
2011 |
Publication |
Journal of Biomedicine & Biotechnology |
Abbreviated Journal |
J Biomed Biotechnol |
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Volume |
2011 |
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Pages  |
520816 |
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Keywords |
Cell Differentiation/physiology; Cell- and Tissue-Based Therapy/*methods; Embryonic Stem Cells/cytology/*physiology/transplantation; Humans; Induced Pluripotent Stem Cells/*physiology/transplantation; Nervous System Diseases/pathology/*therapy; Pluripotent Stem Cells/cytology/*transplantation; Stem Cell Transplantation |
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Abstract |
Although there are a number of weaknesses for clinical use, pluripotent stem cells are valuable sources for patient-specific cell therapies against various diseases. Backed-up by a huge number of basic researches, neuronal differentiation mechanism is well established and pluripotent stem cell therapies against neurological disorders are getting closer to clinical application. However, there are increasing needs for standardization of the sourcing pluripotent stem cells by establishing stem cell registries and banking. Global harmonization will accelerate practical use of personalized therapies using pluripotent stem cells. |
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Division of Intractable Diseases, Center for Biomedical Science, Korea National Institute of Health, Cheongwon-gun, Chungbuk 363-700, Republic of Korea |
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1110-7243 |
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PMID:22203784; PMCID:PMC3238807 |
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refbase @ user @ |
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16957 |
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Author |
Muller, M.; Seufferlein, T.; Illing, A.; Homann, J. |
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Title |
Modelling human channelopathies using induced pluripotent stem cells: a comprehensive review |
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Journal Article |
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Year |
2013 |
Publication |
Stem Cells International |
Abbreviated Journal |
Stem Cells Int |
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Volume |
2013 |
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Pages |
496501 |
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Abstract |
The generation of induced pluripotent stem cells (iPS cells) has pioneered the field of regenerative medicine and developmental biology. They can be generated by overexpression of a defined set of transcription factors in somatic cells derived from easily accessible tissues such as skin or plucked hair or even human urine. In case of applying this tool to patients who are classified into a disease group, it enables the generation of a disease- and patient-specific research platform. iPS cells have proven a significant tool to elucidate pathophysiological mechanisms in various diseases such as diabetes, blood disorders, defined neurological disorders, and genetic liver disease. One of the first successfully modelled human diseases was long QT syndrome, an inherited cardiac channelopathy which causes potentially fatal cardiac arrhythmia. This review summarizes the efforts of reprogramming various types of long QT syndrome and discusses the potential underlying mechanisms and their application. |
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Department of Internal Medicine I, University Hospital of Ulm, Albert-Einstein Allee 23, 89081 Ulm, Germany |
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1687-966X |
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PMID:23766769; PMCID:PMC3666272 |
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refbase @ user @ |
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16884 |
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Giannozzi, P.; Baroni, S.; Bonini, N.; Calandra, M.; Car, R.; Cavazzoni, C.; Ceresoli, D.; Chiarotti, G.L.; Cococcioni, M.; Dabo, I.; Dal Corso, A.; de Gironcoli, S.; Fabris, S.; Fratesi, G.; Gebauer, R.; Gerstmann, U.; Gougoussis, C.; Kokalj, A.; Lazzeri, M.; Martin-Samos, L.; Marzari, N.; Mauri, F.; Mazzarello, R.; Paolini, S.; Pasquarello, A.; Paulatto, L.; Sbraccia, C.; Scandolo, S.; Sclauzero, G.; Seitsonen, A.P.; Smogunov, A.; Umari, P.; Wentzcovitch, R.M. |
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Title |
QUANTUM ESPRESSO: a modular and open-source software project for quantum simulations of materials |
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Journal Article |
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Year |
2009 |
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Journal of Physics: Condensed Matter |
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21 |
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39 |
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395502 |
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0953-8984 |
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refbase @ admin @ Qe-2009 |
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8515 |
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Author |
Abshirini, H.; Rashidi, I.; Saki, N. |
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Title |
Pathologic fractures: a neglected clinical feature of parathyroid adenoma |
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Journal Article |
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Year |
2010 |
Publication |
Case Reports in Medicine |
Abbreviated Journal |
Case Report Med |
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Volume |
2010 |
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357029 |
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The pattern of clinical presentation of primary hyperparathyroidism (pHPT) has changed dramatically from a severe disease to an asymptomatic condition in Western countries. The story is completely different in Eastern countries. Bone and joint related sign and symptoms like bone pain and multiple fractures are common in these patients. Imaging and nuclear medicine studies will be helpful specially in patient who candidate for surgical removal of the abnormal parathyroid gland. Here, we present a 48-year-old man with multiple typical fractures in long bones and a single adenoma in his right inferior parathyroid gland. pHPT is a severe, symptomatic disease with serious complications and high morbidity in Iran. Advanced skeletal disease is the most common pattern of presentation. |
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Otolaryngology, Head and Neck Surgery, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, P.O. Box 61537-15794, Ahvaz, Iran |
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1687-9635 |
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PMID:21209742 |
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Call Number |
refbase @ user @ |
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10153 |
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Author |
Abshirini, H.; Rashidi, I.; Saki, N. |
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Title |
Pathologic fractures: a neglected clinical feature of parathyroid adenoma |
Type |
Journal Article |
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Year |
2010 |
Publication |
Case Reports in Medicine |
Abbreviated Journal |
Case Report Med |
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Volume |
2010 |
Issue |
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Pages |
357029 |
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Keywords |
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Abstract |
The pattern of clinical presentation of primary hyperparathyroidism (pHPT) has changed dramatically from a severe disease to an asymptomatic condition in Western countries. The story is completely different in Eastern countries. Bone and joint related sign and symptoms like bone pain and multiple fractures are common in these patients. Imaging and nuclear medicine studies will be helpful specially in patient who candidate for surgical removal of the abnormal parathyroid gland. Here, we present a 48-year-old man with multiple typical fractures in long bones and a single adenoma in his right inferior parathyroid gland. pHPT is a severe, symptomatic disease with serious complications and high morbidity in Iran. Advanced skeletal disease is the most common pattern of presentation. |
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Address |
Otolaryngology, Head and Neck Surgery, Imam Khomeini Hospital, Ahvaz Jundishapur University of Medical Sciences, P.O. Box 61537-15794, Ahvaz, Iran |
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1687-9635 |
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PMID:21209742 |
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Call Number |
refbase @ user @ |
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10827 |
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