| Records |
| Author |
Wu, Y.; Li, Q.; Rutstrom, D.J.; Zhuravleva, M.; Loyd, M.; Stand, L.; Koschan, M.; Melcher, C.L. |
| Title |
Tailoring the properties of europium-doped potassium calcium iodide scintillators through defect engineering |
Type |
Journal Article |
| Year |
2018 |
Publication |
Phys. Status Solidi RRL |
Abbreviated Journal |
|
| Volume |
12 |
Issue |
|
Pages  |
1700403 |
| Keywords |
|
| Abstract |
|
| Address |
|
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
|
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
|
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
|
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
17746 |
| Permanent link to this record |
| |
|
| |
| Author |
Reller, C.; Krause, R.; Volkova, E.; Schmid, B.; Neubauer, S.; Rucki, A.; Schuster, M.; Schmid, G. |
| Title |
Selective Electroreduction of CO 2 toward Ethylene on Nano Dendritic Copper Catalysts at High Current Density |
Type |
Journal Article |
| Year |
2017 |
Publication |
Advanced Energy Materials |
Abbreviated Journal |
|
| Volume |
7 |
Issue |
12 |
Pages |
1602114 |
| Keywords |
ethylene |
| Abstract |
|
| Address |
|
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
|
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
1614-6832 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
|
Approved |
no |
| Call Number |
refbase @ user @ rellerSelectiveElectroreductionCO2017 |
Serial |
17690 |
| Permanent link to this record |
| |
|
| |
| Author |
Bharti, K.; Gasper, M.; Ou, J.; Brucato, M.; Clore-Gronenborn, K.; Pickel, J.; Arnheiter, H. |
| Title |
A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development |
Type |
Journal Article |
| Year |
2012 |
Publication |
PLoS Genetics |
Abbreviated Journal |
PLoS Genet |
| Volume |
8 |
Issue |
7 |
Pages |
e1002757 |
| Keywords |
Animals; Cell Transdifferentiation; Embryonic Development; *Eye Proteins/genetics/metabolism; Fibroblast Growth Factors/genetics/metabolism; Gene Dosage; Gene Expression Regulation, Developmental; *Homeodomain Proteins/genetics/metabolism; Intercellular Signaling Peptides and Proteins/genetics/metabolism; Mice; *Microphthalmia-Associated Transcription Factor/genetics/metabolism; PAX6 Transcription Factor; *Paired Box Transcription Factors/genetics/metabolism; *Repressor Proteins/genetics/metabolism; Retina/*growth & development/metabolism; Retinal Pigment Epithelium/*growth & development/metabolism; *Wnt Signaling Pathway/genetics |
| Abstract |
The separation of the optic neuroepithelium into future retina and retinal pigment epithelium (RPE) is a critical event in early eye development in vertebrates. Here we show in mice that the transcription factor PAX6, well-known for its retina-promoting activity, also plays a crucial role in early pigment epithelium development. This role is seen, however, only in a background genetically sensitized by mutations in the pigment cell transcription factor MITF. In fact, a reduction in Pax6 gene dose exacerbates the RPE-to-retina transdifferentiation seen in embryos homozygous for an Mitf null allele, and it induces such a transdifferentiation in embryos that are either heterozygous for the Mitf null allele or homozygous for an RPE-specific hypomorphic Mitf allele generated by targeted mutation. Conversely, an increase in Pax6 gene dose interferes with transdifferentiation even in homozygous Mitf null embryos. Gene expression analyses show that, together with MITF or its paralog TFEC, PAX6 suppresses the expression of Fgf15 and Dkk3. Explant culture experiments indicate that a combination of FGF and DKK3 promote retina formation by inhibiting canonical WNT signaling and stimulating the expression of retinogenic genes, including Six6 and Vsx2. Our results demonstrate that in conjunction with Mitf/Tfec Pax6 acts as an anti-retinogenic factor, whereas in conjunction with retinogenic genes it acts as a pro-retinogenic factor. The results suggest that careful manipulation of the Pax6 regulatory circuit may facilitate the generation of retinal and pigment epithelium cells from embryonic or induced pluripotent stem cells. |
| Address |
Mammalian Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America. kapilbharti@ninds.nih.gov |
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
English |
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
1553-7390 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
PMID:22792072; PMCID:PMC3390378 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
16933 |
| Permanent link to this record |
| |
|
| |
| Author |
Higham, P.A.; Vokey, J.R. |
| Title |
Illusory recollection and dual-process models of recognition memory |
Type |
Journal Article |
| Year |
2004 |
Publication |
Quarterly Journal of Experimental Psychology |
Abbreviated Journal |
|
| Volume |
57 |
Issue |
4 |
Pages |
714744 |
| Keywords |
|
| Abstract |
|
| Address |
|
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
|
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
|
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
|
Approved |
no |
| Call Number |
refbase @ user @ Higham2004a |
Serial |
5669 |
| Permanent link to this record |
| |
|
| |
| Author |
Jongkamonwiwat, N.; Noisa, P. |
| Title |
Biomedical and clinical promises of human pluripotent stem cells for neurological disorders |
Type |
Journal Article |
| Year |
2013 |
Publication |
BioMed Research International |
Abbreviated Journal |
Biomed Res Int |
| Volume |
2013 |
Issue |
|
Pages |
656531 |
| Keywords |
Animals; Disease Models, Animal; Humans; Neural Stem Cells/*metabolism/transplantation; Neurodegenerative Diseases/*metabolism/*therapy; Neurons/*metabolism; Pluripotent Stem Cells/*metabolism; *Regeneration; *Stem Cell Transplantation |
| Abstract |
Neurological disorders are characterized by the chronic and progressive loss of neuronal structures and functions. There is a variability of the onsets and causes of clinical manifestations. Cell therapy has brought a new concept to overcome brain diseases, but the advancement of this therapy is limited by the demands of specialized neurons. Human pluripotent stem cells (hPSCs) have been promised as a renewable resource for generating human neurons for both laboratory and clinical purposes. By the modulations of appropriate signalling pathways, desired neuron subtypes can be obtained, and induced pluripotent stem cells (iPSCs) provide genetically matched neurons for treating patients. These hPSC-derived neurons can also be used for disease modeling and drug screening. Since the most urgent problem today in transplantation is the lack of suitable donor organs and tissues, the derivation of neural progenitor cells from hPSCs has opened a new avenue for regenerative medicine. In this review, we summarize the recent reports that show how to generate neural derivatives from hPSCs, and discuss the current evidence of using these cells in animal studies. We also highlight the possibilities and concerns of translating these hPSC-derived neurons for biomedical and clinical uses in order to fight against neurological disorders. |
| Address |
Faculty of Health Sciences, Srinakharinwirot University, Ongkharak, Nakhon Nayok 26120, Thailand |
| Corporate Author |
|
Thesis |
|
| Publisher |
|
Place of Publication |
|
Editor |
|
| Language |
English |
Summary Language |
|
Original Title |
|
| Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
| Series Volume |
|
Series Issue |
|
Edition |
|
| ISSN |
2314-6141 |
ISBN |
|
Medium |
|
| Area |
|
Expedition |
|
Conference |
|
| Notes |
PMID:24171168; PMCID:PMC3793324 |
Approved |
no |
| Call Number |
refbase @ user @ |
Serial |
16862 |
| Permanent link to this record |
