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Author Dana, H.R.; El Mansori, M. openurl 
  Title Mechanical characterisation of anisotropic silica sand/furan resin compound induced by binder jet 3D additive manufacturing technology Type Journal Article
  Year 2020 Publication Ceramics international Abbreviated Journal  
  Volume 46 Issue 11 Pages (down) 17867-17880  
  Keywords 3D sand print process ; Compression test ; Mechanical characterisation ; Microstructural ; Printing parameter  
  Abstract Binder jet 3D printing of ceramic materials is an additive manufacturing technology that enables the production of complex and multi-functional parts through the selective jet binding of precursor powder beds. The present study makes use of the 3D Sand Printing (3DSP) process to create moulds and cores in the casting industry. The use of the 3DSP components as functional parts in industrial production is limited due to the uncertainty associated with their mechanical properties, such as their permeability and thermal stability. Moreover, because of the porous nature of their printed structures, their mechanical properties are dispersed and rather difficult to reproduce. This study aims to characterise the impact of different printing parameters on the mechanical performance of printed parts. For this purpose, a specific device was made in order to assess the mechanical characteristics of samples printed via this technique. The effects of processing parameters such as the printing orientation and building direction on the compressive properties of the printed specimens have also been carefully studied. Microstructural analyses were performed to better understand the relationship between the 3DSP process and the mechanical properties of the components produced from it. The results show that the mechanical tests carried out significantly improve the property reproducibility of the samples made using this technique.  
  Address  
  Corporate Author Thesis  
  Publisher Elsevier Ltd Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0272-8842 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number 1 @ metmet3 @ DanaH.Ramezani2020Mcoa Serial 17821  
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Author Chamberlain, S.J.; Chen, P.-F.; Ng, K.Y.; Bourgois-Rocha, F.; Lemtiri-Chlieh, F.; Levine, E.S.; Lalande, M. url  doi
openurl 
  Title Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader-Willi syndromes Type Journal Article
  Year 2010 Publication Proceedings of the National Academy of Sciences of the United States of America Abbreviated Journal Proc Natl Acad Sci U S A  
  Volume 107 Issue 41 Pages (down) 17668-17673  
  Keywords Angelman Syndrome/*genetics; Cell Differentiation/*physiology; DNA Primers/genetics; Electrophysiology; Genomic Imprinting/*genetics; Humans; Immunohistochemistry; *Models, Biological; Neurons/physiology; Pluripotent Stem Cells/*physiology; Polymerase Chain Reaction; Prader-Willi Syndrome/*genetics; Ubiquitin-Protein Ligases/genetics  
  Abstract Angelman syndrome (AS) and Prader-Willi syndrome (PWS) are neurodevelopmental disorders of genomic imprinting. AS results from loss of function of the ubiquitin protein ligase E3A (UBE3A) gene, whereas the genetic defect in PWS is unknown. Although induced pluripotent stem cells (iPSCs) provide invaluable models of human disease, nuclear reprogramming could limit the usefulness of iPSCs from patients who have AS and PWS should the genomic imprint marks be disturbed by the epigenetic reprogramming process. Our iPSCs derived from patients with AS and PWS show no evidence of DNA methylation imprint erasure at the cis-acting PSW imprinting center. Importantly, we find that, as in normal brain, imprinting of UBE3A is established during neuronal differentiation of AS iPSCs, with the paternal UBE3A allele repressed concomitant with up-regulation of the UBE3A antisense transcript. These iPSC models of genomic imprinting disorders will facilitate investigation of the AS and PWS disease processes and allow study of the developmental timing and mechanism of UBE3A repression in human neurons.  
  Address University of Connecticut Stem Cell Institute and Departments of Genetics and Developmental Biology and Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, USA. chamberlain@uchc.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0027-8424 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:20876107; PMCID:PMC2955112 Approved no  
  Call Number refbase @ user @ Serial 17001  
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Author Lee, M.M.; Childs-Disney, J.L.; Pushechnikov, A.; French, J.M.; Sobczak, K.; Thornton, C.A.; Disney, M.D. openurl 
  Title Controlling the Specificity of Modularly Assembled Small Molecules for RNA via Ligand Module Spacing: Targeting the RNAs That Cause Myotonic Muscular Dystrophy Type Journal Article
  Year 2009 Publication J. Am. Chem. Soc. Abbreviated Journal  
  Volume 131 Issue 47 Pages (down) 17464-17472  
  Keywords Gene Role: BSU (Biological study, unclassified), BIOL (Biological study) (DMPK, RNA from; controlling specificity of modularly assembled small mols. for RNA via ligand module spacing, targeting repetitive RNAs that interact with MBNL1 and cause myotonic muscular dystrophy); Proteins Role: BSU (Biological study, unclassified), BIOL (Biological study) (MBNL1 (Muscleblind-like 1 protein); controlling specificity of modularly assembled small mols. for RNA via ligand module spacing, targeting repetitive RNAs that interact with MBNL1 and cause myotonic muscular dystrophy); Gene Role: BSU (Biological study, unclassified), BIOL (Biological study) (ZNF9, RNA from; controlling specificity of modularly assembled small mols. for RNA via ligand module spacing, targeting repetitive RNAs that interact with MBNL1 and cause myotonic muscular dystrophy); Mutation (expansion, of repetitive DNA; controlling specificity of modularly assembled small mols. for RNA via ligand module spacing, targeting repetitive RNAs that interact with MBNL1 and cause myotonic muscular dystrophy); Muscular dystrophy (myotonic; controlling specificity of modularly assembled small mols. for RNA via ligand module spacing, targeting repetitive RNAs that interact with MBNL1 and cause myotonic muscular dystrophy); Molecular association (of MBNL1 with RNA repeats, disruption of; controlling specificity of modularly assembled small mols. for RNA via ligand module spacing, targeting repetitive RNAs that interact with MBNL1 and cause myotonic muscular dystrophy); RNA Role: ADV (Adverse effect, including toxicity), BSU (Biological study, unclassified), BIOL (Biological study) (repetitive; controlling specificity of modularly assembled small mols. for RNA via ligand module spacing, targeting repetitive RNAs that interact with MBNL1 and cause myotonic muscular dystrophy)  
  Abstract Myotonic muscular dystrophy types 1 and 2 (DM1 and DM2, resp.) are caused by expansions of repeating nucleotides in noncoding regions of RNA. In DM1, the expansion is an rCUG triplet repeat, whereas the DM2 expansion is an rCCUG quadruplet repeat. Both RNAs fold into hairpin structures with periodically repeating internal loops sepd. by two 5'GC/3'CG base pairs. The sizes of the loops, however, are different: the DM1 repeat forms 1 * 1 nucleotide UU loops while the DM2 repeat forms 2 * 2 nucleotide 5'CU/3'UC loops. DM is caused when the expanded repeats bind the RNA splicing regulator Muscleblind-like 1 protein (MBNL1), thus compromising its function. Therefore, one potential therapeutic strategy for these diseases is to prevent MBNL1 from binding the toxic RNA repeats. Previously, we designed nanomolar inhibitors of the DM2-MBNL1 interaction by modularly assembling 6'-N-5-hexyonate kanamycin A (K) onto a peptoid backbone. The K ligand binds the 2 * 2 pyrimidine-rich internal loops found in the DM2 RNA with high affinity. The best compd. identified from that study contains three K modules sepd. by four propylamine spacing modules and is 20-fold selective for the DM2 RNA over the DM1 RNA. Because the modularly assembled K-contg. compds. also bound the DM1 RNA, albeit with lower affinity, and because the loop size is different, we hypothesized that the optimal DM1 RNA binder may display K modules sepd. by a shorter distance. Indeed, here the ideal DM1 RNA binder has only two propylamine spacing modules sepg. the K ligands. Peptoids displaying three and four K modules on a peptoid scaffold bind the DM1 RNA with Kd's of 20 nM (3-fold selective for DM1 over DM2) and 4 nM (6-fold selective) and inhibit the RNA-protein interaction with IC50's of 40 and 7 nM, resp. Importantly, by coupling the two studies together, we have detd. that appropriate spacing can affect binding selectivity by 60-fold (20- * 3-fold). The trimer and tetramer also bind .apprx.13- and .apprx.63-fold more tightly to DM1 RNAs than does MBNL1. The modularly assembled compds. are cell permeable and nontoxic as detd. by flow cytometry. The results establish that for these two systems: (i) a programmable modular assembly approach can provide synthetic ligands for RNA with affinities and specificities that exceed those of natural proteins; and, (ii) the spacing of ligand modules can be used to tune specificity for one RNA target over another.  
  Address Department of Chemistry and The Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0002-7863 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number refbase @ admin @ Serial 7312  
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Author Munneke, P.K.; Reijmer, C.H.; van den Broeke, M.R.; Konig-Langlo, G.; Stammes, P.; Knap, W.H. openurl 
  Title Analysis of clear-sky Antarctic snow albedo using observations and radiative transfer modeling Type Journal Article
  Year 2008 Publication Journal of Geophysical Research-Atmospheres Abbreviated Journal  
  Volume 113 Issue D17 Pages (down) 17118  
  Keywords  
  Abstract A radiative transfer model for studying spectral and broadband snow surface albedo has been applied to radiation data (1998-2001) from different climate regimes in Antarctica. The model makes use of the doubling-adding method for radiative transfer, combined with the correlated k-distribution technique to account for atmospheric gas absorption. Snow layers are described by scattering phase functions for irregular hexagonal plate-shaped ice crystals. Multiple scattering is included, as well as the option to include soot in the snowpack, as well as clouds. Sensitivity experiments show that the model is capable of calculating spectral and broadband albedos as a function of solar zenith angle and effective snow grain radius re. The novel approach of applying the model to multiple-year field data of clear-sky albedo from five locations in Dronning Maud Land, Antarctica, reveals that seasonal clear-sky albedo variations (0.77-0.88) are dominantly caused by strong spatial and temporal variations in re. Summer season averages of re range from 22 mm on the Antarctic plateau to 64 mm on the ice shelf. Maximum monthly values of re are 40-150% higher. Other factors influencing clear-sky broadband albedo are the seasonal cycle in solar zenith angle (at most 0.02 difference in summer and spring/autumn albedo) and the spatial variation in optical thickness of the cloudless atmosphere (0.01 difference between ice shelves and plateau). The seasonal cycle in optical thickness of the atmosphere was found to be of minor importance (< 0.005 between summer and spring/autumn).  
  Address  
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  Notes Approved no  
  Call Number refbase @ admin @ Munneke2008 Serial 8103  
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Author Anisimov, V.I.; Solovyev, I.V.; Korotin, M.A. url  openurl
  Title Density-functional theory and NiO photoemission spectra Type Journal Article
  Year 1993 Publication Physical Review B Abbreviated Journal  
  Volume 48 Issue 23 Pages (down) 16929-16934  
  Keywords  
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  Series Volume Series Issue Edition  
  ISSN 0163-1829 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number refbase @ admin @ Anisimov1993 Serial 8516  
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