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Author Larimore, J.; Ryder, P.V.; Kim, K.-Y.; Ambrose, L.A.; Chapleau, C.; Calfa, G.; Gross, C.; Bassell, G.J.; Pozzo-Miller, L.; Smith, Y.; Talbot, K.; Park, I.-H.; Faundez, V. url  doi
openurl 
  Title MeCP2 regulates the synaptic expression of a Dysbindin-BLOC-1 network component in mouse brain and human induced pluripotent stem cell-derived neurons Type Journal Article
  Year 2013 Publication PloS one Abbreviated Journal PLoS One  
  Volume 8 Issue 6 Pages (down) e65069  
  Keywords Animals; Carrier Proteins/genetics/*metabolism; Computational Biology; Dystrophin-Associated Proteins; *Gene Expression Regulation; Hippocampus/*cytology; Humans; Induced Pluripotent Stem Cells/cytology; Lectins/genetics/*metabolism; Methyl-CpG-Binding Protein 2/deficiency/*metabolism; Mice; Neurons/cytology/*metabolism; Protein Interaction Maps; RNA, Messenger/genetics/metabolism; Synapses/*metabolism  
  Abstract Clinical, epidemiological, and genetic evidence suggest overlapping pathogenic mechanisms between autism spectrum disorder (ASD) and schizophrenia. We tested this hypothesis by asking if mutations in the ASD gene MECP2 which cause Rett syndrome affect the expression of genes encoding the schizophrenia risk factor dysbindin, a subunit of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), and associated interacting proteins. We measured mRNA and protein levels of key components of a dysbindin interaction network by, quantitative real time PCR and quantitative immunohistochemistry in hippocampal samples of wild-type and Mecp2 mutant mice. In addition, we confirmed results by performing immunohistochemistry of normal human hippocampus and quantitative qRT-PCR of human inducible pluripotent stem cells (iPSCs)-derived human neurons from Rett syndrome patients. We defined the distribution of the BLOC-1 subunit pallidin in human and mouse hippocampus and contrasted this distribution with that of symptomatic Mecp2 mutant mice. Neurons from mutant mice and Rett syndrome patients displayed selectively reduced levels of pallidin transcript. Pallidin immunoreactivity decreased in the hippocampus of symptomatic Mecp2 mutant mice, a feature most prominent at asymmetric synapses as determined by immunoelectron microcopy. Pallidin immunoreactivity decreased concomitantly with reduced BDNF content in the hippocampus of Mecp2 mice. Similarly, BDNF content was reduced in the hippocampus of BLOC-1 deficient mice suggesting that genetic defects in BLOC-1 are upstream of the BDNF phenotype in Mecp2 deficient mice. Our results demonstrate that the ASD-related gene Mecp2 regulates the expression of components belonging to the dysbindin interactome and these molecular differences may contribute to synaptic phenotypes that characterize Mecp2 deficiencies and ASD.  
  Address Department of Biology, Agnes Scott College, Decatur, Georgia, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1932-6203 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23750231; PMCID:PMC3672180 Approved no  
  Call Number refbase @ user @ Serial 16886  
Permanent link to this record
 

 
Author Humpenöder, F.; Popp, A.; Dietrich, J.P.; Klein, D.; Lotze-Campen, H.; Bonsch, M.; Bodirsky, B.L.; Weindl, I.; Stevanovic, M.; Müller, C. url  openurl
  Title Investigating afforestation and bioenergy CCS as climate change mitigation strategies Type Journal Article
  Year 2014 Publication Environmental Research Letters Abbreviated Journal  
  Volume 9 Issue 6 Pages (down) 064029  
  Keywords CropM; TradeM; tst  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1748-9326 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number refbase @ user @ Serial 16599  
Permanent link to this record
 

 
Author Abbott, B.P.; Abbott, R.; Adhikari, R.; Ajith, P.; Allen, B.; Allen, G.; Amin, R.S.; Anderson, S.B.; Anderson, W.G.; Arain, M.A.; Araya, M.; Armandula, H.; Armor, P.; Aso, Y.; Aston, S.; Aufmuth, P.; Aulbert, C.; Babak, S.; Baker, P.; Ballmer, S.; Barker, C.; Barker, D.; Barr, B.; Barriga, P.; Barsotti, L.; Barton, M.A.; Bartos, I.; Bassiri, R.; Bastarrika, M.; Behnke, B.; Benacquista, M.; Betzwieser, J.; Beyersdorf, P.T.; Bilenko, I.A.; Billingsley, G.; Biswas, R.; Black, E.; Blackburn, J.K.; Blackburn, L.; Blair, D.; Bland, B.; Bodiya, T.P.; Bogue, L.; Bork, R.; Boschi, V.; Bose, S.; Brady, P.R.; Braginsky, V.B.; Brau, J.E.; Bridges, D.O.; Brinkmann, M.; Brooks, A.F.; Brown, D.A.; Brummit, A.; Brunet, G.; Bullington, A.; Buonanno, A.; Burmeister, O.; Byer, R.L.; Cadonati, L.; Camp, J.B.; Cannizzo, J.; Cannon, K.C.; Cao, J.; Cardenas, L.; Caride, S.; Castaldi, G.; Caudill, S.; Cavaglia, M.; Cepeda, C.; Chalermsongsak, T.; Chalkley, E.; Charlton, P.; Chatterji, S.; Chelkowski, S.; Chen, Y.; Christensen, N.; Chung, C.T.Y.; Clark, D.; Clark, J.; Clayton, J.H.; Cokelaer, T.; Colacino, C.N.; Conte, R.; Cook, D.; Corbitt, T.R.C.; Cornish, N.; Coward, D.; Coyne, D.C.; Creighton, J.D.E.; Creighton, T.D.; Cruise, A.M.; Culter, R.M.; Cumming, A.; Cunningham, L.; Danilishin, S.L.; Danzmann, K.; Daudert, B.; Davies, G.; Daw, E.J.; DeBra, D.; Degallaix, J.; Dergachev, V.; Desai, S.; DeSalvo, R.; Dhurandhar, S.; Diaz, M.; Dietz, A.; Donovan, F.; Dooley, K.L.; Doomes, E.E.; Drever, R.W.P.; Dueck, J.; Duke, I.; Dumas, J.C.; Dwyer, J.G.; Echols, C.; Edgar, M.; Effler, A.; Ehrens, P.; Espinoza, E.; Etzel, T.; Evans, M.; Evans, T.; Fairhurst, S.; Faltas, Y.; Fan, Y.; Fazi, D.; Fehrmann, H.; Finn, L.S.; Flasch, K.; Foley, S.; Forrest, C.; Fotopoulos, N.; Franzen, A.; Frede, M.; Frei, M.; Frei, Z.; Freise, A.; Frey, R.; Fricke, T.; Fritschel, P.; Frolov, V.V.; Fyffe, M.; Galdi, V.; Garofoli, J.A.; Gholami, I.; Giaime, J.A.; Giampanis, S.; Giardina, K.D.; Goda, K.; Goetz, E.; Goggin, L.M.; Gonzalez, G.; Gorodetsky, M.L.; Goßler, S.; Gouaty, R.; Grant, A.; Gras, S.; Gray, C.; Gray, M.; Greenhalgh, R.J.S.; Gretarsson, A.M.; Grimaldi, F.; Grosso, R.; Grote, H.; Grunewald, S.; Guenther, M.; Gustafson, E.K.; Gustafson, R.; Hage, B.; Hallam, J.M.; Hammer, D.; Hammond, G.D.; Hanna, C.; Hanson, J.; Harms, J.; Harry, G.M.; Harry, I.W.; Harstad, E.D.; Haughian, K.; Hayama, K.; Heefner, J.; Heng, I.S.; Heptonstall, A.; Hewitson, M.; Hild, S.; Hirose, E.; Hoak, D.; Hodge, K.A.; Holt, K.; Hosken, D.J.; Hough, J.; Hoyland, D.; Hughey, B.; Huttner, S.H.; Ingram, D.R.; Isogai, T.; Ito, M.; Ivanov, A.; Johnson, B.; Johnson, W.W.; Jones, D.I.; Jones, G.; Jones, R.; Ju, L.; Kalmus, P.; Kalogera, V.; Kandhasamy, S.; Kanner, J.; Kasprzyk, D.; Katsavounidis, E.; Kawabe, K.; Kawamura, S.; Kawazoe, F.; Kells, W.; Keppel, D.G.; Khalaidovski, A.; Khalili, F.Y.; Khan, R.; Khazanov, E.; King, P.; Kissel, J.S.; Klimenko, S.; Kokeyama, K.; Kondrashov, V.; Kopparapu, R.; Koranda, S.; Kozak, D.; Krishnan, B.; Kumar, R.; Kwee, P.; Lam, P.K.; Landry, M.; Lantz, B.; Lazzarini, A.; Lei, H.; Lei, M.; Leindecker, N.; Leonor, I.; Li, C.; Lin, H.; Lindquist, P.E.; Littenberg, T.B.; Lockerbie, N.A.; Lodhia, D.; Longo, M.; Lormand, M.; Lu, P.; Lubinski, M.; Lucianetti, A.; Lueck, H.; Machenschalk, B.; MacInnis, M.; Mageswaran, M.; Mailand, K.; Mandel, I.; Mandic, V.; Márka, S.; Márka, Z.; Markosyan, A.; Markowitz, J.; Maros, E.; Martin, I.W.; Martin, R.M.; Marx, J.N.; Mason, K.; Matichard, F.; Matone, L.; Matzner, R.A.; Mavalvala, N.; McCarthy, R.; McClclland, D.E.; McGuire, S.C.; McHugh, M.; McIntyre, G.; McKechan, D.J.A.; McKenzie, K.; Mehmet, M.; Melatos, A.; Melissinos, A.C.; Menéndez, D.F.; Mendell, G.; Mercer, R.A.; Meshkov, S.; Messenger, C.; Meyer, M.S.; Miller, J.; Minelli, J.; Mino, Y.; Mitrofanov, V.P.; Mitselmakher, G.; Mittleman, R.; Miyakawa, O.; Moe, B.; Mohanty, S.D.; Mohapatra, S.R.P.; Moreno, G.; Morioka, T.; Mors, K.; Mossavi, K.; MowLowry, C.; Mueller, G.; Müller-Ebhardt, H.; Muhammad, D.; Mukherjee, S.; Mukhopadhyay, H.; Mullavey, A.; Munch, J.; Murray, P.G.; Myers, E.; Myers, J.; Nash, T.; Nelson, J.; Newton, G.; Nishizawa, A.; Numata, K.; ODell, J.; OReilly, B.; OShaughnessy, R.; Ochsner, E.; Ogin, G.H.; Ottaway, D.J.; Ottens, R.S.; Overmier, H.; Owen, B.J.; Pan, Y.; Pankow, C.; Papa, M.A.; Parameshwaraiah, V.; Patel, P.; Pedraza, M.; Penn, S.; Perreca, A.; Pierro, V.; Pinto, I.M.; Pitkin, M.; Pletsch, H.J.; Plissi, M.V.; Postiglione, F.; Principe, M.; Prix, R.; Prokhorov, L.; Punken, O.; Quetschke, V.; Raab, F.J.; Rabeling, D.S.; Radkins, H.; Raffai, P.; Raics, Z.; Rainer, N.; Rakhmanov, M.; Raymond, V.; Reed, C.M.; Reed, T.; Rehbein, H.; Reid, S.; Reitze, D.H.; Riesen, R.; Riles, K.; Rivera, B.; Roberts, P.; Robertson, N.A.; Robinson, C.; Robinson, E.L.; Roddy, S.; Röver, C.; Rollins, J.; Romano, J.D.; Romie, J.H.; Rowan, S.; Rüdiger, A.; Russell, P.; Ryan, K.; Sakata, S.; de la Jordana, L.S.; Sandberg, V.; Sannibale, V.; Santamaría, L.; Saraf, S.; Sarin, P.; Sathyaprakash, B.S.; Sato, S.; Satterthwaite, M.; Saulson, P.R.; Savage, R.; Savov, P.; Scanlan, M.; Schilling, R.; Schnabel, R.; Schofield, R.; Schulz, B.; Schutz, B.F.; Schwinberg, P.; Scott, J.; Scott, S.M.; Searle, A.C.; Sears, B.; Seifert, F.; Sellers, D.; Sengupta, A.S.; Sergeev, A.; Shapiro, B.; Shawhan, P.; Shoemaker, D.H.; Sibley, A.; Siemens, X.; Sigg, D.; Sinha, S.; Sintes, A.M.; Slagmolen, B.J.J.; Slutsky, J.; Smith, J.R.; Smith, M.R.; Smith, N.D.; Somiya, K.; Sorazu, B.; Stein, A.; Stein, L.C.; Steplewski, S.; Stochino, A.; Stone, R.; Strain, K.A.; Strigin, S.; Stroeer, A.; Stuver, A.L.; Summerscales, T.Z.; Sun, K.X.; Sung, M.; Sutton, P.J.; Szokoly, G.P.; Talukder, D.; Tang, L.; Tanner, D.B.; Tarabrin, S.P.; Taylor, J.R.; Taylor, R.; Thacker, J.; Thorne, K.A.; Thorne, K.S.; Thüring, A.; Tokmakov, K.V.; Torres, C.; Torrie, C.; Traylor, G.; Trias, M.; Ugolini, D.; Ulmen, J.; Urbanek, K.; Vahlbruch, H.; Vallisneri, M.; Van den Broeck, C.; van der Sluys, M.V.; van Veggel, A.A.; Vass, S.; Vaulin, R.; Vecchio, A.; Veitch, J.; Veitch, P.; Veltkamp, C.; Villar, A.; Vorvick, C.; Vyachanin, S.P.; Waldman, S.J.; Wallace, L.; Ward, R.L.; Weidner, A.; Weinert, M.; Weinstein, A.J.; Weiss, R.; Wen, L.; Wen, S.; Wette, K.; Whelan, J.T.; Whitcomb, S.E.; Whiting, B.F.; Wilkinson, C.; Willems, P.A.; Williams, H.R.; Williams, L.; Willke, B.; Wilmut, I.; Winkelmann, L.; Winkler, W.; Wipf, C.C.; Wiseman, A.G.; Woan, G.; Wooley, R.; Worden, J.; Wu, W.; Yakushin, I.; Yamamoto, H.; Yan, Z.; Yoshida, S.; Zanolin, M.; Zhang, J.; Zhang, L.; Zhao, C.; Zotov, N.; Zucker, M.E.; zur Mühlen, H.; Zweizig, J.; Collaboration, the L.I.G.O.S. openurl 
  Title First LIGO search for gravitational wave bursts from cosmic (super)strings Type Journal Article
  Year 2009 Publication Physical Review D Abbreviated Journal  
  Volume 80 Issue 6 Pages (down) 062002  
  Keywords  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication One Physics Ellipse, College Pk, Md 20740-3844 Usa Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1550-7998 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number refbase @ admin @ Abbott2009f Serial 12845  
Permanent link to this record
 

 
Author Abbott, B.P.; Abbott, R.; Adhikari, R.; Ajith, P.; Allen, B.; Allen, G.; Amin, R.S.; Anderson, S.B.; Anderson, W.G.; Arain, M.A.; Araya, M.; Armandula, H.; Armor, P.; Aso, Y.; Aston, S.; Aufmuth, P.; Aulbert, C.; Babak, S.; Baker, P.; Ballmer, S.; Barker, C.; Barker, D.; Barr, B.; Barriga, P.; Barsotti, L.; Barton, M.A.; Bartos, I.; Bassiri, R.; Bastarrika, M.; Behnke, B.; Benacquista, M.; Betzwieser, J.; Beyersdorf, P.T.; Bilenko, I.A.; Billingsley, G.; Biswas, R.; Black, E.; Blackburn, J.K.; Blackburn, L.; Blair, D.; Bland, B.; Bodiya, T.P.; Bogue, L.; Bork, R.; Boschi, V.; Bose, S.; Brady, P.R.; Braginsky, V.B.; Brau, J.E.; Bridges, D.O.; Brinkmann, M.; Brooks, A.F.; Brown, D.A.; Brummit, A.; Brunet, G.; Bullington, A.; Buonanno, A.; Burmeister, O.; Byer, R.L.; Cadonati, L.; Camp, J.B.; Cannizzo, J.; Cannon, K.C.; Cao, J.; Cardenas, L.; Cardoso, V.; Caride, S.; Castaldi, G.; Caudill, S.; Cavaglia, M.; Cepeda, C.; Chalermsongsak, T.; Chalkley, E.; Charlton, P.; Chatterji, S.; Chelkowski, S.; Chen, Y.; Christensen, N.; Chung, C.T.Y.; Clark, D.; Clark, J.; Clayton, J.H.; Cokelaer, T.; Colacino, C.N.; Conte, R.; Cook, D.; Corbitt, T.R.C.; Cornish, N.; Coward, D.; Coyne, D.C.; Creighton, J.D.E.; Creighton, T.D.; Cruise, A.M.; Culter, R.M.; Cumming, A.; Cunningham, L.; Danilishin, S.L.; Danzmann, K.; Daudert, B.; Davies, G.; Daw, E.J.; DeBra, D.; Degallaix, J.; Dergachev, V.; Desai, S.; DeSalvo, R.; Dhurandhar, S.; Diaz, M.; Dietz, A.; Donovan, F.; Dooley, K.L.; Doomes, E.E.; Drever, R.W.P.; Dueck, J.; Duke, I.; Dumas, J.C.; Dwyer, J.G.; Echols, C.; Edgar, M.; Effler, A.; Ehrens, P.; Espinoza, E.; Etzel, T.; Evans, M.; Evans, T.; Fairhurst, S.; Faltas, Y.; Fan, Y.; Fazi, D.; Fehrmann, H.; Finn, L.S.; Flasch, K.; Foley, S.; Forrest, C.; Fotopoulos, N.; Franzen, A.; Frede, M.; Frei, M.; Frei, Z.; Freise, A.; Frey, R.; Fricke, T.; Fritschel, P.; Frolov, V.V.; Fyffe, M.; Galdi, V.; Garofoli, J.A.; Gholami, I.; Giaime, J.A.; Giampanis, S.; Giardina, K.D.; Goda, K.; Goetz, E.; Goggin, L.M.; Gonzalez, G.; Gorodetsky, M.L.; Goßler, S.; Gouaty, R.; Grant, A.; Gras, S.; Gray, C.; Gray, M.; Greenhalgh, R.J.S.; Gretarsson, A.M.; Grimaldi, F.; Grosso, R.; Grote, H.; Grunewald, S.; Guenther, M.; Gustafson, E.K.; Gustafson, R.; Hage, B.; Hallam, J.M.; Hammer, D.; Hammond, G.D.; Hanna, C.; Hanson, J.; Harms, J.; Harry, G.M.; Harry, I.W.; Harstad, E.D.; Haughian, K.; Hayama, K.; Heefner, J.; Heng, I.S.; Heptonstall, A.; Hewitson, M.; Hild, S.; Hirose, E.; Hoak, D.; Hodge, K.A.; Holt, K.; Hosken, D.J.; Hough, J.; Hoyland, D.; Hughey, B.; Huttner, S.H.; Ingram, D.R.; Isogai, T.; Ito, M.; Ivanov, A.; Johnson, B.; Johnson, W.W.; Jones, D.I.; Jones, G.; Jones, R.; Ju, L.; Kalmus, P.; Kalogera, V.; Kandhasamy, S.; Kanner, J.; Kasprzyk, D.; Katsavounidis, E.; Kawabe, K.; Kawamura, S.; Kawazoe, F.; Kells, W.; Keppel, D.G.; Khalaidovski, A.; Khalili, F.Y.; Khan, R.; Khazanov, E.; King, P.; Kissel, J.S.; Klimenko, S.; Kokeyama, K.; Kondrashov, V.; Kopparapu, R.; Koranda, S.; Kozak, D.; Krishnan, B.; Kumar, R.; Kwee, P.; Lam, P.K.; Landry, M.; Lantz, B.; Lazzarini, A.; Lei, H.; Lei, M.; Leindecker, N.; Leonor, I.; Li, C.; Lin, H.; Lindquist, P.E.; Littenberg, T.B.; Lockerbie, N.A.; Lodhia, D.; Longo, M.; Lormand, M.; Lu, P.; Lubinski, M.; Lucianetti, A.; Lueck, H.; Machenschalk, B.; MacInnis, M.; Mageswaran, M.; Mailand, K.; Mandel, I.; Mandic, V.; Márka, S.; Márka, Z.; Markosyan, A.; Markowitz, J.; Maros, E.; Martin, I.W.; Martin, R.M.; Marx, J.N.; Mason, K.; Matichard, F.; Matone, L.; Matzner, R.A.; Mavalvala, N.; McCarthy, R.; McClelland, D.E.; McGuire, S.C.; McHugh, M.; McIntyre, G.; McKechan, D.J.A.; McKenzie, K.; Mehmet, M.; Melatos, A.; Melissinos, A.C.; Menéndez, D.F.; Mendell, G.; Mercer, R.A.; Meshkov, S.; Messenger, C.; Meyer, M.S.; Miller, J.; Minelli, J.; Mino, Y.; Mitrofanov, V.P.; Mitselmakher, G.; Mittleman, R.; Miyakawa, O.; Moe, B.; Mohanty, S.D.; Mohapatra, S.R.P.; Moreno, G.; Morioka, T.; Mors, K.; Mossavi, K.; MowLowry, C.; Mueller, G.; Müller-Ebhardt, H.; Muhammad, D.; Mukherjee, S.; Mukhopadhyay, H.; Mullavey, A.; Munch, J.; Murray, P.G.; Myers, E.; Myers, J.; Nash, T.; Nelson, J.; Newton, G.; Nishizawa, A.; Numata, K.; ODell, J.; OReilly, B.; OShaughnessy, R.; Ochsner, E.; Ogin, G.H.; Ottaway, D.J.; Ottens, R.S.; Overmier, H.; Owen, B.J.; Pan, Y.; Pankow, C.; Papa, M.A.; Parameshwaraiah, V.; Patel, P.; Pedraza, M.; Penn, S.; Perraca, A.; Pierro, V.; Pinto, I.M.; Pitkin, M.; Pletsch, H.J.; Plissi, M.V.; Postiglione, F.; Principe, M.; Prix, R.; Prokhorov, L.; Punken, O.; Quetschke, V.; Raab, F.J.; Rabeling, D.S.; Radkins, H.; Raffai, P.; Raics, Z.; Rainer, N.; Rakhmanov, M.; Raymond, V.; Reed, C.M.; Reed, T.; Rehbein, H.; Reid, S.; Reitze, D.H.; Riesen, R.; Riles, K.; Rivera, B.; Roberts, P.; Robertson, N.A.; Robinson, C.; Robinson, E.L.; Roddy, S.; Röver, C.; Rollins, J.; Romano, J.D.; Romie, J.H.; Rowan, S.; Rüdiger, A.; Russell, P.; Ryan, K.; Sakata, S.; de la Jordana, L.S.; Sandberg, V.; Sannibale, V.; Santamaría, L.; Saraf, S.; Sarin, P.; Sathyaprakash, B.S.; Sato, S.; Satterthwaite, M.; Saulson, P.R.; Savage, R.; Savov, P.; Scanlan, M.; Schilling, R.; Schnabel, R.; Schofield, R.; Schulz, B.; Schutz, B.F.; Schwinberg, P.; Scott, J.; Scott, S.M.; Searle, A.C.; Sears, B.; Seifert, F.; Sellers, D.; Sengupta, A.S.; Sergeev, A.; Shapiro, B.; Shawhan, P.; Shoemaker, D.H.; Sibley, A.; Siemens, X.; Sigg, D.; Sinha, S.; Sintes, A.M.; Slagmolen, B.J.J.; Slutsky, J.; Smith, J.R.; Smith, M.R.; Smith, N.D.; Somiya, K.; Sorazu, B.; Stein, A.; Stein, L.C.; Steplewski, S.; Stochino, A.; Stone, R.; Strain, K.A.; Strigin, S.; Stroeer, A.; Stuver, A.L.; Summerscales, T.Z.; Sun, K.X.; Sung, M.; Sutton, P.J.; Szokoly, G.P.; Talukder, D.; Tang, L.; Tanner, D.B.; Tarabrin, S.P.; Taylor, J.R.; Taylor, R.; Thacker, J.; Thorne, K.A.; Thorne, K.S.; Thüring, A.; Tokmakov, K.V.; Torres, C.; Torrie, C.; Traylor, G.; Trias, M.; Ugolini, D.; Ulmen, J.; Urbanek, K.; Vahlbruch, H.; Vallisneri, M.; Van den Broeck, C.; van der Sluys, M.V.; van Veggel, A.A.; Vass, S.; Vaulin, R.; Vecchio, A.; Veitch, J.; Veitch, P.; Veltkamp, C.; Villar, A.; Vorvick, C.; Vyachanin, S.P.; Waldman, S.J.; Wallace, L.; Ward, R.L.; Weidner, A.; Weinert, M.; Weinstein, A.J.; Weiss, R.; Wen, L.; Wen, S.; Wette, K.; Whelan, J.T.; Whitcomb, S.E.; Whiting, B.F.; Wilkinson, C.; Willems, P.A.; Williams, H.R.; Williams, L.; Willke, B.; Wilmut, I.; Winkelmann, L.; Winkler, W.; Wipf, C.C.; Wiseman, A.G.; Woan, G.; Wooley, R.; Worden, J.; Wu, W.; Yakushin, I.; Yamamoto, H.; Yan, Z.; Yoshida, S.; Zanolin, M.; Zhang, J.; Zhang, L.; Zhao, C.; Zotov, N.; Zucker, M.E.; zur Mühlen, H.; Zweizig, J.; Collaboration, the L.I.G.O.S. openurl 
  Title Search for gravitational wave ringdowns from perturbed black holes in LIGO S4 data Type Journal Article
  Year 2009 Publication Physical Review D Abbreviated Journal  
  Volume 80 Issue 6 Pages (down) 062001  
  Keywords  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication One Physics Ellipse, College Pk, Md 20740-3844 Usa Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1550-7998 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number refbase @ admin @ Abbott2009e Serial 12844  
Permanent link to this record
 

 
Author Zeng, L.; Zhang, P.; Shi, L.; Yamamoto, V.; Lu, W.; Wang, K. url  doi
openurl 
  Title Functional impacts of NRXN1 knockdown on neurodevelopment in stem cell models Type Journal Article
  Year 2013 Publication PloS one Abbreviated Journal PLoS One  
  Volume 8 Issue 3 Pages (down) e59685  
  Keywords Astrocytes/cytology/metabolism; Cell Adhesion Molecules, Neuronal/*genetics/*metabolism; Cell Differentiation/genetics; DNA Transposable Elements; Developmental Disabilities/genetics/metabolism; Gene Expression Regulation; Gene Knockdown Techniques; Humans; Induced Pluripotent Stem Cells/cytology/metabolism; Nerve Tissue Proteins/*genetics/*metabolism; Neural Stem Cells/cytology/metabolism; Neurons/cytology/metabolism; Protein Interaction Maps; Signal Transduction; Stem Cells/*cytology/*metabolism  
  Abstract Exonic deletions in NRXN1 have been associated with several neurodevelopmental disorders, including autism, schizophrenia and developmental delay. However, the molecular mechanism by which NRXN1 deletions impact neurodevelopment remains unclear. Here we used human induced pluripotent stem cells (hiPSCs) and human embryonic stem cells (hESCs) as models to investigate the functional impacts of NRXN1 knockdown. We first generated hiPSCs from skin fibroblasts and differentiated them into neural stem cells (NSCs). We reduced NRXN1 expression in NSCs via a controlled shRNAmir-based knockdown system during differentiation, and monitored the transcriptome alteration by RNA-Seq and quantitative PCR at several time points. Interestingly, half reduction of NRXN1 expression resulted in changes of expression levels for the cell adhesion pathway (20 genes, P = 2.8x10(-6)) and neuron differentiation pathway (13 genes, P = 2.1x10(-4)), implicating that single-gene perturbation can impact biological networks important for neurodevelopment. Furthermore, astrocyte marker GFAP was significantly reduced in a time dependent manner that correlated with NRXN1 reduction. This observation was reproduced in both hiPSCs and hESCs. In summary, based on in vitro models, NRXN1 deletions impact several biological processes during neurodevelopment, including synaptic adhesion and neuron differentiation. Our study highlights the utility of stem cell models in understanding the functional roles of copy number variations (CNVs) in conferring susceptibility to neurodevelopmental diseases.  
  Address Zilhka Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1932-6203 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23536886; PMCID:PMC3607566 Approved no  
  Call Number refbase @ user @ Serial 16899  
Permanent link to this record
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