toggle visibility Search & Display Options

Select All    Deselect All
 |   | 
  Record Links
Author (up) openurl 
  Title Type Miscellaneous
  Year Publication Abbreviated Journal  
  Volume Issue Pages  
  Abstract DOI (1-100 micrograms/kg i.v.) induced an increase in mean blood pressure in the anaesthetized rat.Similarly, in the pithed rat, DOI (1-100 micrograms/kg i.v.) induced a dose-dependent increase in mean blood pressure, as did 5-HT.However, in contrast to 5-HT, DOI did not change the heart rate in either intact or pithed rats.In the pithed rat, the dose-pressor response curves to both 5-HT and DOI were unaffected by MDL 72222 (5-HT3 receptor antagonist), spiroxatrine or (+/-)-pindolol (5-HT1A receptor antagonists), idazoxan (alpha 2-adrenoceptor blocking agent) and AR-C 239 (alpha 1-adrenoceptor blocking agent).Only the selective 5-HT2 receptor antagonist.LY 53857, significantly and dose dependently shifted to the right the dose-response curves to both 5-HT and DOI.These results indicated that DOI possesses 5-HT2 agonistic properties and that the pressor response induced by DOI in the pithed rat is mediated via 5-HT2 receptors.  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number refbase @ user @ ref25 Serial 9455  
Permanent link to this record
Select All    Deselect All
 |   | 

Save Citations:
Export Records: