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Author (up) Mestivier, D.; Dabire, H.; Chau, N.P. isbn  openurl
  Title Effects of autonomic blockers on linear and nonlinear indexes of blood pressure and heart rate in SHR Type Miscellaneous
  Year 2001 Publication Abbreviated Journal  
  Volume Issue Pages H1113-H1121.  
  Keywords autonomic, blockers, indexes, blood, pressure, heart, heart rate, SHR, 2001/08/22 10:00  
  Abstract Recent results in normotensive Wistar-Kyoto (WKY) rats show that nonlinear method may be more specific to quantify sympathetic and parasympathetic activities than the low (LF) and high frequencies (HF) spectral powers of blood pressure (BP) and R-R interval (RR). The present study extends this conclusion to spontaneously hypertensive rats (SHR). Blood pressure was recorded for 30 min before and after intravenous injection of saline, hexamethonium, atropine, atenolol, or prazosin. Mean level, standard deviation (SD), spectral LF and HF components, and three nonlinear indexes (percentage of recurrence, percentage of determinism, and length index of the recurrence plot method) were used to analyze the BP and RR signals. In conscious SHR, sympathetic but not parasympathetic blockade reduced BP level and LF-BP, and increased nonlinear indexes of BP. RR increased after beta-sympathetic and ganglionic blockade, decreased after parasympathetic blockade, and remained unchanged after alpha(1)-sympathetic blockade. SD-RR decreased after ganglionic and alpha(1) blockade, whereas HF-RR increased after beta-sympathetic blockade. The effects on nonlinear indexes of RR are clear and consistent: only alpha(1)-blockade increased the indexes. Our nonlinear indexes may be useful to investigate cardiovascular functions in normotension and hypertension.  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title Journal Article  
  Series Volume 281 Series Issue 3 Edition  
  ISSN ISBN 0363-6135 Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number refbase @ user @ Mestivier2001 Serial 9021  
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