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Author (up) Alderson, R.F.; Curtis, R.; Alterman, A.L.; Lindsay, R.M.; DiStefano, P.S. url  openurl
  Title Truncated TrkB mediates the endocytosis and release of BDNF and neurotrophin-4/5 by rat astrocytes and Schwann cells in vitro Type Journal Article
  Year 2000 Publication Brain Research Abbreviated Journal  
  Volume 871 Issue 2 Pages 210-222  
  Keywords hippocampus ; neurotrophin ; glia cells; sciatic nerve  
  Abstract Binding and cross-linking studies with radiolabeled neurotrophins demonstrate that cultured rat hippocampal astrocytes lack full-length TrkB, but do express high levels of truncated TrkB (tTrkB). In astrocytes and Schwann cells, tTrkB appears to have the novel function of mediating the endocytosis of neurotrophins into an acid-stable, Triton X-100 resistant intracellular pool that is released back into the medium in a temperature-dependent manner. Chloroquine treatment, trichloroacetic acid solubility, and sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis revealed that when incubated with astrocytes or Schwann cells for at least 48 h neither the intracellular nor the released neurotrophins were significantly degraded. The endocytosis and release of neurotrophins may represent a novel mechanism whereby neuroglia can regulate the local concentration of these neurotrophic factors for extended periods of time. (C) 2000 Elsevier Science B.V. All rights reserved.  
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  Notes Alderson, RF: ralph_alderson@hgsi.com Jul 21 2000 0006-8993 Approved no  
  Call Number refbase @ admin @ Alderson2000 Serial 823  
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