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Author Aron, A.R.; Schlaghecken, F.; Fletcher, P.C.; Bullmore, E.T.; Eimer, M.; Barker, R.; Sahakian, B.J.; Robbins, T.W. url  openurl
  Title Inhibition of subliminally primed responses is mediated by the caudate and thalamus: Evidence from functional MRI and Huntington's disease Type Journal Article
  Year 2003 Publication Brain: A Journal of Neurology Abbreviated Journal  
  Volume 126 Issue 3 Pages 713-723  
  Keywords subliminally primed responses; caudate; thalamus; Huntington's disease; corticostriatal-pallidal-thalamic pathway; Caudate Nucleus; Huntingtons Disease; Neuropsychology; Priming  
  Abstract The present study investigated the possibility that inhibitory control processes are mediated by a corticostriatal-pallidal-thalamic pathway by using a masked prime task with Huntington's disease patients and with healthy volunteers in a functional MRI (fMRI) study. In the masked prime task, clearly visible left- or right-pointing target arrows are preceded by briefly presented and subsequently masked prime arrows. Participants respond quickly with a left or right key-press to each target. Trials are either compatible or incompatible. Prior behavioural and electrophysiological results show that automatic inhibition of the initially primed response tendency is reflected in a 'negative compatibility effect', and is shown to consist of three distinct processes occurring within 300 ms. Experiment 1 tested the hypothesis that lesions of the striatum would interrupt automatic inhibitory control by studying early-stage Huntington's disease patients. Findings supported the hypothesis: there was a bimodal distribution for patients, with one-third showing disinhibition, manifested as an absent negative compatibility effect, and two-thirds showing excessive inhibition, manifested as a significantly greater negative compatibility effect than that in controls. (PsycINFO Database Record (c) 2006 APA, all rights reserved)  
  Corporate Author Thesis  
  Publisher Oxford Univ Press Place of Publication Robbins, T. W., Department of Experimental Psychology, University of Cambridge, Cambridge, United Ki Editor  
  Language Summary Language Original Title  
  Series Editor Series Title (up) Abbreviated Series Title  
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  Notes 0006-89501460-2156Accession Number: 2003-01574-013. First Author & Affiliation: Aron, A. R.; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom. Release Date: 20040503. Publication Type: Journal; Peer Reviewed Journal. Media Covered: Print. Media Available: Electronic; Print. Document Type: Original Journal Article. Language: English. Major Descriptor(s): Caudate Nucleus; Huntingtons Disease; Neuropsychology; Priming; Thalamus. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10)Male (30)Female (40). Age Group:Adulthood (18 yrs & older) (300); . References Available: Y. Approved no  
  Call Number refbase @ user @ Aron2003 Serial 6546  
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