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Author (up) Aron, A.R.; Schlaghecken, F.; Fletcher, P.C.; Bullmore, E.T.; Eimer, M.; Barker, R.; Sahakian, B.J.; Robbins, T.W.
Title Inhibition of subliminally primed responses is mediated by the caudate and thalamus: Evidence from functional MRI and Huntington's disease Type Journal Article
Year 2003 Publication Brain: A Journal of Neurology Abbreviated Journal
Volume 126 Issue 3 Pages 713-723
Keywords subliminally primed responses; caudate; thalamus; Huntington's disease; corticostriatal-pallidal-thalamic pathway; Caudate Nucleus; Huntingtons Disease; Neuropsychology; Priming
Abstract The present study investigated the possibility that inhibitory control processes are mediated by a corticostriatal-pallidal-thalamic pathway by using a masked prime task with Huntington's disease patients and with healthy volunteers in a functional MRI (fMRI) study. In the masked prime task, clearly visible left- or right-pointing target arrows are preceded by briefly presented and subsequently masked prime arrows. Participants respond quickly with a left or right key-press to each target. Trials are either compatible or incompatible. Prior behavioural and electrophysiological results show that automatic inhibition of the initially primed response tendency is reflected in a 'negative compatibility effect', and is shown to consist of three distinct processes occurring within 300 ms. Experiment 1 tested the hypothesis that lesions of the striatum would interrupt automatic inhibitory control by studying early-stage Huntington's disease patients. Findings supported the hypothesis: there was a bimodal distribution for patients, with one-third showing disinhibition, manifested as an absent negative compatibility effect, and two-thirds showing excessive inhibition, manifested as a significantly greater negative compatibility effect than that in controls. (PsycINFO Database Record (c) 2006 APA, all rights reserved)
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Publisher Oxford Univ Press Place of Publication Robbins, T. W., Department of Experimental Psychology, University of Cambridge, Cambridge, United Ki Editor
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Notes 0006-89501460-2156Accession Number: 2003-01574-013. First Author & Affiliation: Aron, A. R.; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom. Release Date: 20040503. Publication Type: Journal; Peer Reviewed Journal. Media Covered: Print. Media Available: Electronic; Print. Document Type: Original Journal Article. Language: English. Major Descriptor(s): Caudate Nucleus; Huntingtons Disease; Neuropsychology; Priming; Thalamus. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10)Male (30)Female (40). Age Group:Adulthood (18 yrs & older) (300); . References Available: Y. Approved no
Call Number refbase @ user @ Aron2003 Serial 6546
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