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Aron, A.R.; Schlaghecken, F.; Fletcher, P.C.; Bullmore, E.T.; Eimer, M.; Barker, R.; Sahakian, B.J.; Robbins, T.W. |

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Title |
Inhibition of subliminally primed responses is mediated by the caudate and thalamus: Evidence from functional MRI and Huntington's disease |
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Journal Article |
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Year |
2003 |
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Brain: A Journal of Neurology |
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126 |
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3 |
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713-723 |
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subliminally primed responses; caudate; thalamus; Huntington's disease; corticostriatal-pallidal-thalamic pathway; Caudate Nucleus; Huntingtons Disease; Neuropsychology; Priming |
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Abstract |
The present study investigated the possibility that inhibitory control processes are mediated by a corticostriatal-pallidal-thalamic pathway by using a masked prime task with Huntington's disease patients and with healthy volunteers in a functional MRI (fMRI) study. In the masked prime task, clearly visible left- or right-pointing target arrows are preceded by briefly presented and subsequently masked prime arrows. Participants respond quickly with a left or right key-press to each target. Trials are either compatible or incompatible. Prior behavioural and electrophysiological results show that automatic inhibition of the initially primed response tendency is reflected in a 'negative compatibility effect', and is shown to consist of three distinct processes occurring within 300 ms. Experiment 1 tested the hypothesis that lesions of the striatum would interrupt automatic inhibitory control by studying early-stage Huntington's disease patients. Findings supported the hypothesis: there was a bimodal distribution for patients, with one-third showing disinhibition, manifested as an absent negative compatibility effect, and two-thirds showing excessive inhibition, manifested as a significantly greater negative compatibility effect than that in controls. (PsycINFO Database Record (c) 2006 APA, all rights reserved) |
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Oxford Univ Press |
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Robbins, T. W., Department of Experimental Psychology, University of Cambridge, Cambridge, United Ki |
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0006-89501460-2156Accession Number: 2003-01574-013. First Author & Affiliation: Aron, A. R.; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom. Release Date: 20040503. Publication Type: Journal; Peer Reviewed Journal. Media Covered: Print. Media Available: Electronic; Print. Document Type: Original Journal Article. Language: English. Major Descriptor(s): Caudate Nucleus; Huntingtons Disease; Neuropsychology; Priming; Thalamus. Classification: Physical & Somatoform & Psychogenic Disorders (3290). Population: Human (10)Male (30)Female (40). Age Group:Adulthood (18 yrs & older) (300); . References Available: Y. |
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refbase @ user @ Aron2003 |
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6546 |
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