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Jovanovic, T.; Norrholm, S.D.; Keyes, M.; Fiallos, A.; Jovanovic, S.; Myers, K.M.; Davis, M.; Duncan, E.J. |

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Title |
Contingency Awareness and Fear Inhibition in a Human Fear-Potentiated Startle Paradigm |
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Journal Article |
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Year |
2006 |
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Behavioral Neuroscience |
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120 |
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5 |
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995-1004 |
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human startle response; contingency awareness; discrimination learning; fear inhibition; Awareness; Fear; Response Inhibition; Startle Reflex |
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Fear-potentiated startle is defined as an increase in the magnitude of the startle reflex in the presence of a stimulus that was previously paired with an aversive event. It has been proposed that a subject's awareness of the contingencies in the experiment may affect fear-potentiated startle. The authors adapted a conditional discrimination procedure (AX+/BX-), previously validated in animals, to a human fear-potentiated startle paradigm in 50 healthy volunteers. This paradigm allows for an assessment of fear-potentiated startle during threat conditions as well as inhibition of fear-potentiated startle during safety conditions. A response keypad was used to assess contingency awareness on a trial-by-trial basis. Both aware and unaware subjects showed fear-potentiated startle. However, awareness was related to stimulus discrimination and fear inhibition. (PsycINFO Database Record (c) 2007 APA, all rights reserved) (from the journal abstract) |
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American Psychological Association |
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Jovanovic, Tanja, Mental Health Service/116A, Atlanta Veterans Affairs Medical Center, 1670 Clairmon |
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0735-7044Accession Number: 2006-12871-001. First Author & Affiliation: Jovanovic, Tanja; Mental Health Service/116A, Atlanta Veterans Affairs Medical Center, Decatur, GA, US. Other Journal Title: Behavioral Neuroscience. Release Date: 20061002. Publication Type: Journal (0100) Peer Reviewed Journal (0110). Media Covered: Electronic. Media Available: Electronic; Print. Document Type: Journal Article. Language: English. Major Descriptor: Awareness; Discrimination Learning; Fear; Response Inhibition; Startle Reflex. Classification: Psychophysiology (2560) . Population: Human (10) Male (30) Female (40) . Location: US. Age Group: Adulthood (18 yrs & older) (300) Young Adulthood (18-29 yrs) (320) Thirties (30-39 yrs) (340) Middle Age (40-64 yrs) (360) Aged (65 yrs & older) (380) . Grant Information: This research was supported by the Mental Health Service, Atlanta Veterans Affairs Medical Center; the Science and Technology Center Program, Center for Behavioral Neuroscience, National Science Foundation under Agreement No. IBN-9876754 (Venture grant to Erica J. Duncan, principal investigator [PI]); the American Psychiatric Association and GlaxoSmithKline (Erica J. Duncan, PI); National Institute of Mental Health Grants 1R24MH067314-01A1 (B. Rothbaum, PI) and R37 MH47840 (Michael Davis, PI); Kirschstein National Research Service Award Individual Fellowship 1F32 MH070129-01A2 (Tanja Jovanovic, PI); and the Woodruff Foundation, Emory University School of Medicine. Tests & Measures: Structured Clinical Interview for DSM-IV Axis I Disorders; . Methodology: Empirical Study; Quantitative Study. References Available: Y. |
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refbase @ user @ Jovanovic2006 |
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5526 |
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