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Author (up) Burnett, A.L.; Strong, T.D.; Trock, B.J.; Jin, L.; Bivalacqua, T.J.; Musicki, B. openurl 
  Title Serum Biomarker Measurements of Endothelial Function and Oxidative Stress After Daily Dosing of Sildenafil in Type 2 Diabetic Men With Erectile Dysfunction Type Journal Article
  Year 2008 Publication J Urol Abbreviated Journal  
  Volume Issue Pages  
  Abstract PURPOSE: We investigated changes in serum biomarkers of vascular function in men with type 2 diabetes with erectile dysfunction in association with erectile function outcomes after short-term, continuous sildenafil dosing. MATERIALS AND METHODS: Men with erectile dysfunction associated with type 2 diabetes mellitus were randomized to receive continuous, daily sildenafil (50 mg for 1 week run-in and 100 mg for 3 weeks) (148), or placebo (144) for 4 weeks (phase I) and then sildenafil (25, 50 or 100 mg) on demand for 12 weeks (phase II). Blood draws at baseline and after phases I and II were analyzed for cyclic guanosine monophosphate (endothelial function marker), 8-isoprostane (oxidative stress marker), and interleukin-6 and interleukin-8 (inflammatory cytokines). Primary and secondary erectile function outcome variables were affirmative responses on Sexual Encounter Profile question 3 (ability to maintain erection sufficient for sexual intercourse) and Erection Hardness Score, respectively. RESULTS: Serum cyclic guanosine monophosphate levels were increased in the sildenafil group relative to the placebo group at 4 (p  
  Corporate Author Thesis  
  Publisher Place of Publication Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Inst Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1527-3792 (Electronic) ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number refbase @ admin @ Burnett2008 Serial 4155  
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