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Author (up) Lee, S.P.; Yeoh, L.; Harris, N.D.; Davies, C.M.; Robinson, R.T.; Leathard, A.; Newman, C.; Macdonald, I.A.; Heller, S.R. url  openurl
  Title Influence of autonomic neuropathy on QTc interval lengthening during hypoglycemia in type 1 diabetes Type Journal Article
  Year 2004 Publication Diabetes Abbreviated Journal  
  Volume 53 Issue 6 Pages 1535-1542  
  Keywords Adult; Autonomic Nervous System; Autonomic Nervous System Diseases; Blood Pressure; Case-Control Studies; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Electrocardiography; Epinephrine; Female; Glucose Clamp Technique; Heart; Humans; Hypoglycemia; Male; Norepinephrine; Potassium  
  Abstract Hypoglycemia produces electrocardiographic QTc lengthening, a predictor of arrhythmia risk and sudden death. This results from both sympatho-adrenal activation and a lowered serum potassium. It has been suggested that cardiac autonomic neuropathy (CAN) might indicate those who are at particular risk. We tested this hypothesis in 28 adults with type 1 diabetes and 8 nondiabetic control subjects. After standard tests of autonomic function and baroreflex sensitivity (BRS) measurement, diabetic participants were divided into three groups: 1) CAN- with normal BRS (BRS+; n = 10), 2) CAN- with impaired BRS (BRS-; n = 9), and 3) CAN+ (n = 9). QTc was then measured during controlled hypoglycemia (2.5 mmol/l) using a hyperinsulinemic clamp. Mean (+/-SE) QTc lengthened from 377 +/- 9 ms (baseline) to a maximum during hypoglycemia of 439 +/- 13 ms in BRS+ subjects and from 378 +/- 5 to 439 +/- 10 ms in control subjects. Peak QTc tended to be lower in CAN+ (baseline, 383 +/- 6; maximum, 408 +/- 10) and BRS- groups (baseline, 380 +/- 8; maximum, 421 +/- 11; F = 1.7, P = 0.18). Peak epinephrine concentrations (nmol/l) were 3.1 +/- 0.8 (BRS+), 2.6 +/- 0.5 (BRS-), 1.4 +/- 0.3 (CAN+), and 5.7 +/- 0.8 (control subjects). These data do not indicate that those with CAN are at particular risk for abnormal cardiac repolarization during hypoglycemia. Indeed, they suggest that such patients may be relatively protected, perhaps as a result of attenuated sympatho-adrenal responses.  
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  ISSN 0012-1797 ISBN Medium  
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  Notes Approved no  
  Call Number refbase @ user @ Lee2004 Serial 2217  
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