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Author Kunkanjanawan, T.; Noisa, P.; Parnpai, R. url  doi
  Title Modeling neurological disorders by human induced pluripotent stem cells Type Journal Article
  Year 2011 Publication Journal of Biomedicine & Biotechnology Abbreviated Journal J Biomed Biotechnol  
  Volume 2011 Issue Pages 350131  
  Keywords (up) Brain/embryology/physiopathology; Cell Differentiation; Embryonic Stem Cells/*cytology; Humans; Induced Pluripotent Stem Cells/*cytology/*physiology; *Models, Neurological; Nervous System Diseases/*pathology/*physiopathology/therapy  
  Abstract Studies of human brain development are critical as research on neurological disorders have been progressively advanced. However, understanding the process of neurogenesis through analysis of the early embryo is complicated and limited by a number of factors, including the complexity of the embryos, availability, and ethical constrains. The emerging of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) has shed light of a new approach to study both early development and disease pathology. The cells behave as precursors of all embryonic lineages; thus, they allow tracing the history from the root to individual branches of the cell lineage tree. Systems for neural differentiation of hESCs and iPSCs have provided an experimental model that can be used to augment in vitro studies of in vivo brain development. Interestingly, iPSCs derived from patients, containing donor genetic background, have offered a breakthrough approach to study human genetics of neurodegenerative diseases. This paper summarizes the recent reports of the development of iPSCs from patients who suffer from neurological diseases and evaluates the feasibility of iPSCs as a disease model. The benefits and obstacles of iPSC technology are highlighted in order to raising the cautions of misinterpretation prior to further clinical translations.  
  Address Embryo Technology and Stem Cell Research Center, School of Biotechnology, Suranaree University of Technology, 111 University Avenue, Nakhon Ratchasima 30000, Thailand  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1110-7243 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22162635; PMCID:PMC3227533 Approved no  
  Call Number refbase @ user @ Serial 16958  
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