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Author (up) Paulsen, B. da S.; da Silveira, M.S.; Galina, A.; Rehen, S.K. url  doi
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  Title Pluripotent stem cells as a model to study oxygen metabolism in neurogenesis and neurodevelopmental disorders Type Journal Article
  Year 2013 Publication Archives of Biochemistry and Biophysics Abbreviated Journal Arch Biochem Biophys  
  Volume 534 Issue 1-2 Pages 3-10  
  Keywords Epigenesis, Genetic; Humans; Induced Pluripotent Stem Cells/cytology/*metabolism; Mitochondria/metabolism; Models, Neurological; *Neurogenesis; Neurons/metabolism/pathology; Oxidative Stress; Oxygen/*metabolism; Reactive Oxygen Species/metabolism; Schizophrenia/genetics/*metabolism/physiopathology; Signal Transduction  
  Abstract Reactive oxygen species (ROS) and oxygen (O2) have been implicated in neurogenesis and self-renewal of neural progenitor cells (NPCs). On the other hand, oxidative unbalance, either by an impairment of antioxidant defenses or by an intensified production of ROS, is increasingly related to risk factors of neurodevelopmental disorders, such as schizophrenia. In this scenario, human induced pluripotent stem cells (hiPSCs) emerged as an interesting platform for the study of cellular and molecular aspects of this mental disorder, by complementing other experimental models, with exclusive advantages such as the recapitulation of brain development. Herein we discuss the role of O2/ROS signaling for neuronal differentiation and how its unbalance could be related to neurodevelopmental disorders, such as schizophrenia. Identifying the role of O2/ROS in neurogenesis as well as tackling oxidative stress and its disturbances in schizophrenic patients' derived cells will provide an interesting opportunity for the study of neural stem cells differentiation and neurodevelopmental disorders.  
  Address Laboratorio Nacional de Celulas-Tronco Embrionarias, Instituto de Ciencias Biomedicas, UFRJ, Rio de Janeiro RJ 21941-913, Brazil  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0003-9861 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23111185 Approved no  
  Call Number refbase @ user @ Serial 16914  
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