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Author Muller, M.; Seufferlein, T.; Illing, A.; Homann, J. url  doi
  Title Modelling human channelopathies using induced pluripotent stem cells: a comprehensive review Type Journal Article
  Year 2013 Publication (up) Stem Cells International Abbreviated Journal Stem Cells Int  
  Volume 2013 Issue Pages 496501  
  Abstract The generation of induced pluripotent stem cells (iPS cells) has pioneered the field of regenerative medicine and developmental biology. They can be generated by overexpression of a defined set of transcription factors in somatic cells derived from easily accessible tissues such as skin or plucked hair or even human urine. In case of applying this tool to patients who are classified into a disease group, it enables the generation of a disease- and patient-specific research platform. iPS cells have proven a significant tool to elucidate pathophysiological mechanisms in various diseases such as diabetes, blood disorders, defined neurological disorders, and genetic liver disease. One of the first successfully modelled human diseases was long QT syndrome, an inherited cardiac channelopathy which causes potentially fatal cardiac arrhythmia. This review summarizes the efforts of reprogramming various types of long QT syndrome and discusses the potential underlying mechanisms and their application.  
  Address Department of Internal Medicine I, University Hospital of Ulm, Albert-Einstein Allee 23, 89081 Ulm, Germany  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1687-966X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23766769; PMCID:PMC3666272 Approved no  
  Call Number refbase @ user @ Serial 16884  
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