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Author (up) Jongkamonwiwat, N.; Noisa, P. url  doi
openurl 
  Title Biomedical and clinical promises of human pluripotent stem cells for neurological disorders Type Journal Article
  Year 2013 Publication BioMed Research International Abbreviated Journal Biomed Res Int  
  Volume 2013 Issue Pages 656531  
  Keywords Animals; Disease Models, Animal; Humans; Neural Stem Cells/*metabolism/transplantation; Neurodegenerative Diseases/*metabolism/*therapy; Neurons/*metabolism; Pluripotent Stem Cells/*metabolism; *Regeneration; *Stem Cell Transplantation  
  Abstract Neurological disorders are characterized by the chronic and progressive loss of neuronal structures and functions. There is a variability of the onsets and causes of clinical manifestations. Cell therapy has brought a new concept to overcome brain diseases, but the advancement of this therapy is limited by the demands of specialized neurons. Human pluripotent stem cells (hPSCs) have been promised as a renewable resource for generating human neurons for both laboratory and clinical purposes. By the modulations of appropriate signalling pathways, desired neuron subtypes can be obtained, and induced pluripotent stem cells (iPSCs) provide genetically matched neurons for treating patients. These hPSC-derived neurons can also be used for disease modeling and drug screening. Since the most urgent problem today in transplantation is the lack of suitable donor organs and tissues, the derivation of neural progenitor cells from hPSCs has opened a new avenue for regenerative medicine. In this review, we summarize the recent reports that show how to generate neural derivatives from hPSCs, and discuss the current evidence of using these cells in animal studies. We also highlight the possibilities and concerns of translating these hPSC-derived neurons for biomedical and clinical uses in order to fight against neurological disorders.  
  Address Faculty of Health Sciences, Srinakharinwirot University, Ongkharak, Nakhon Nayok 26120, Thailand  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2314-6141 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24171168; PMCID:PMC3793324 Approved no  
  Call Number refbase @ user @ Serial 16862  
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