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Author (up) Acab, A.; Muotri, A.R. url  doi
  Title The Use of Induced Pluripotent Stem Cell Technology to Advance Autism Research and Treatment Type Journal Article
  Year 2015 Publication Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics Abbreviated Journal Neurotherapeutics  
  Volume 12 Issue 3 Pages 534-545  
  Keywords Autism Spectrum Disorder/*drug therapy/genetics/metabolism/*physiopathology; Drug Evaluation, Preclinical; Humans; Induced Pluripotent Stem Cells/drug effects/metabolism/*physiology; Neural Stem Cells/drug effects/metabolism/*physiology; Signal Transduction  
  Abstract Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental disorders sharing a core set of symptoms, including impaired social interaction, language deficits, and repetitive behaviors. While ASDs are highly heritable and demonstrate a clear genetic component, the cellular and molecular mechanisms driving ASD etiology remain undefined. The unavailability of live patient-specific neurons has contributed to the difficulty in studying ASD pathophysiology. The recent advent of induced pluripotent stem cells (iPSCs) has provided the ability to generate patient-specific human neurons from somatic cells. The iPSC field has quickly grown, as researchers have demonstrated the utility of this technology to model several diseases, especially neurologic disorders. Here, we review the current literature around using iPSCs to model ASDs, and discuss the notable findings, and the promise and limitations of this technology. The recent report of a nonsyndromic ASD iPSC model and several previous ASD models demonstrating similar results points to the ability of iPSC to reveal potential novel biomarkers and therapeutics.  
  Address School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular and Molecular Medicine, Stem Cell Program, University of California San Diego, MC 0695, La Jolla, CA, 92093, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1878-7479 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25851569; PMCID:PMC4489954 Approved no  
  Call Number refbase @ user @ Serial 16774  
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