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Author (up) Jodeiri Farshbaf, M.; Ghaedi, K.; Megraw, T.L.; Curtiss, J.; Shirani Faradonbeh, M.; Vaziri, P.; Nasr-Esfahani, M.H. url  doi
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  Title Does PGC1alpha/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders? Type Journal Article
  Year 2016 Publication Neuromolecular Medicine Abbreviated Journal Neuromolecular Med  
  Volume 18 Issue 1 Pages 1-15  
  Keywords Animals; Brain-Derived Neurotrophic Factor/*physiology; Cyclic AMP Response Element-Binding Protein/physiology; Energy Metabolism; Exercise/*physiology; Exercise Therapy; Feedback, Physiological; Fibronectins/*physiology; Humans; Mice; Mitochondria/physiology; Models, Neurological; Nerve Tissue Proteins/*physiology; Neurodegenerative Diseases/physiopathology/*prevention & control; Neurogenesis/physiology; Neurons/physiology/ultrastructure; Organelle Biogenesis; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/*physiology; Peroxisomes/physiology; Signal Transduction/*physiology; Bdnf; Fndc5; Irisin; Neurodegenerative diseases; Neuroprotection; PGC1alpha  
  Abstract Neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's diseases have high prevalence among the elderly. Many strategies have been established to alleviate the symptoms experienced by affected individuals. Recent studies have shown that exercise helps patients with neurological disorders to regain lost physical abilities. PGC1alpha/FNDC5/BDNF has emerged recently as a critical pathway for neuroprotection. PGC1alpha is a highly conserved co-activator of transcription factors that preserves and protects neurons against destruction. PGC1alpha regulates FNDC5 and its processed and secreted peptide Irisin, which has been proposed to play a critical role in energy expenditure and to promote neural differentiation of mouse embryonic stem cells. FNDC5 may also increase the expression of the neurotrophic factor BDNF, a neuroprotective agent, in the hippocampus. BDNF is secreted from hippocampus, amygdala, cerebral cortex and hypothalamus neurons and initiates intracellular signaling pathways through TrkB receptors. These pathways have positive feedback on CREB activities and lead to enhancement in PGC1alpha expression in neurons. Therefore, FNDC5 could behave as a key regulator in neuronal survival and development. This review presents recent findings on the PGC1alpha/FNDC5/BDNF pathway and its role in neuroprotection, and discusses the controversial promise of irisin as a mediator of the positive benefits of exercise.  
  Address Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Royan Street, Salman Street, Khorasgan, Isfahan, 8165131378, Iran. mh_nasr@royaninstitute.org  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1535-1084 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26611102 Approved no  
  Call Number refbase @ user @ Serial 16720  
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