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Author (up) Kelava, I.; Lancaster, M.A. url  doi
openurl 
  Title Dishing out mini-brains: Current progress and future prospects in brain organoid research Type Journal Article
  Year 2016 Publication Developmental Biology Abbreviated Journal Dev Biol  
  Volume 420 Issue 2 Pages 199-209  
  Keywords Cortex; Human brain development; In vitro; Neural differentiation; Neurological disorder; Organoid; Stem cells  
  Abstract The ability to model human brain development in vitro represents an important step in our study of developmental processes and neurological disorders. Protocols that utilize human embryonic and induced pluripotent stem cells can now generate organoids which faithfully recapitulate, on a cell-biological and gene expression level, the early period of human embryonic and fetal brain development. In combination with novel gene editing tools, such as CRISPR, these methods represent an unprecedented model system in the field of mammalian neural development. In this review, we focus on the similarities of current organoid methods to in vivo brain development, discuss their limitations and potential improvements, and explore the future venues of brain organoid research.  
  Address MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, CB2 0QH Cambridge, United Kingdom. Electronic address: mlancast@mrc-lmb.cam.ac.uk  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0012-1606 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27402594; PMCID:PMC5161139 Approved no  
  Call Number refbase @ user @ Serial 16667  
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