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Author (up) Chen, C.; Kim, W.-Y.; Jiang, P. url  doi
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  Title Humanized neuronal chimeric mouse brain generated by neonatally engrafted human iPSC-derived primitive neural progenitor cells Type Journal Article
  Year 2016 Publication JCI Insight Abbreviated Journal JCI Insight  
  Volume 1 Issue 19 Pages e88632  
  Keywords  
  Abstract The creation of a humanized chimeric mouse nervous system permits the study of human neural development and disease pathogenesis using human cells in vivo. Humanized glial chimeric mice with the brain and spinal cord being colonized by human glial cells have been successfully generated. However, generation of humanized chimeric mouse brains repopulated by human neurons to possess a high degree of chimerism have not been well studied. Here we created humanized neuronal chimeric mouse brains by neonatally engrafting the distinct and highly neurogenic human induced pluripotent stem cell (hiPSC)-derived rosette-type primitive neural progenitors. These neural progenitors predominantly differentiate to neurons, which disperse widely throughout the mouse brain with infiltration of the cerebral cortex and hippocampus at 6 and 13 months after transplantation. Building upon the hiPSC technology, we propose that this potentially unique humanized neuronal chimeric mouse model will provide profound opportunities to define the structure, function, and plasticity of neural networks containing human neurons derived from a broad variety of neurological disorders.  
  Address Department of Developmental Neuroscience, Munroe-Meyer Institute,; Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, Nebraska, USA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2379-3708 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27882348; PMCID:PMC5111502 Approved no  
  Call Number refbase @ user @ Serial 16640  
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