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Author  |
Hildebrand, D.G.; Lehle, S.; Borst, A.; Haferkamp, S.; Essmann, F.; Schulze-Osthoff, K. |
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Title |
Fucosidase as a novel convenient biomarker for cellular senescence |
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Journal Article |
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Year |
2013 |
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Cell Cycle |
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12 |
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12 |
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1922-1927 |
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Animals; Biological Markers, metabolism; Cell Aging, genetics/physiology; Cells, Cultured; HCT116 Cells; Humans; Immunohistochemistry; Mice, Inbred ICR; Real-Time Polymerase Chain Reaction; alpha-L-Fucosidase, genetics/metabolism |
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Abstract |
Due to its role in aging and antitumor defense, cellular senescence has recently attracted increasing interest. However, there is currently no single specific marker that can unequivocally detect senescent cells. Here, we identified I2-L-fucosidase (I2-Fuc) as a novel sensitive biomarker for cellular senescence. Regardless of the stress stimulus and cell type, I-Fuc activity was induced in all canonical types of cellular senescence, including replicative, DNA damage- and oncogene-induced senescence. Strikingly, in most models the degree of I-Fuc upregulation was higher than the induction of senescence-associated I2-galactosidase (SA-I2-Gal), the current gold standard for senescence detection. As I-Fuc is convenient and easy to measure, we suggest its utility as a valuable marker, in particular in cells with low SA-I2-Gal activity. |
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refbase @ user @ Hildebrand2013 |
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13018 |
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